The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006
The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006
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DOI：
10.1111/j.1537-2995.2008.01811.x
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发表时间：
2008-09-01
期刊：
影响因子：
2.9
通讯作者：
Benjamin, Richard J.
中科院分区：
文献类型：
--
作者：
Eder, Anne F.;Dy, Beth A.;Benjamin, Richard J.
背景：美国红十字会(ARC)于2003年启动了一项全面的捐赠者血液警戒计划。研究设计与方法：采用单因素和多因素Logistic回归分析2006年36个地区血液中心全血(WB)、分离血小板(PLT)和全自动红细胞(R2)捐献后的并发症发生率，分别为209,815，25,966和12,282例(348.9,577.5和538.3/10,000)。结果：6,014,472例WB，449,594例PLT和228,183例R2术后并发症分别为209,815，25,966和12,282例(348.9,577.5和538.3/10,000)。绝大多数是轻微的突触前反应和小的血肿。地区中心、捐献者年龄、性别和捐献状况与WB、PLT和R2捐献后并发症发生率独立相关。WB和R2捐献后并发症发生率的季节性变化与20岁以下献血者的比例有关。不包括大的血肿，WB、PLT和R2手术的主要并发症的总体发生率分别为每10,000例收集7.4、5.2和3.3例。WB和自动采血的外部医疗服务记录的比率相似(每10,000次献血分别为3.2和2.9)。结论：ARC数据使用标准化定义和报告方案描述了模型多中心血液警戒系统中献血的当前风险。报告的反应率因地区中心的不同而不同，与捐赠者的人口统计学无关，限制了不同地区血液中心的直接比较。
BACKGROUND: The American Red Cross (ARC) initiated a comprehensive donor hemovigilance program in 2003. We provide an overview of reported complications after whole blood (WB), apheresis platelet (PLT), or automated red cell (R2) donation and analyze factors contributing to the variability in reported complication rates in our national program.STUDY DESIGN AND METHODS: Complications recorded at the collection site or reported after allogeneic WB, apheresis PLT, and R2 donation procedures in 36 regional blood centers in 2006 were analyzed by univariate and multivariate logistic regression.RESULTS: Complications after 6,014,472 WB, 449,594 PLT, and 228,183 R2 procedures totaled 209,815, 25,966, and 12,282 (348.9, 577.5, and 538.3 per 10,000 donations), respectively, the vast majority of which were minor presyncopal reactions and small hematomas. Regional center, donor age, sex, and donation status were independently associated with complication rates after WB, PLT, and R2 donation. Seasonal variability in complications rates after WB and R2 donation correlated with the proportion of donors under 20 years old. Excluding large hematomas, the overall rate of major complications was 7.4, 5.2, and 3.3 per 10,000 collections for WB, PLT, and R2 procedures, respectively. Outside medical care was recorded at similar rates for both WB and automated collections (3.2 vs. 2.9 per 10,000 donations, respectively).CONCLUSION: The ARC data describe the current risks of blood donation in a model multicenter hemovigilance system using standardized definitions and reporting protocols. Reported reaction rates varied by regional center independently of donor demographics, limiting direct comparison of different regional blood centers.