Discontinuation of Long-Term Opioid Therapy in Patients With Versus Without Dementia.
Discontinuation of Long-Term Opioid Therapy in Patients With Versus Without Dementia.
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DOI：
10.1016/j.amepre.2021.07.020
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发表时间：
2022-03
影响因子：
5.5
通讯作者：
Winterstein AG
中科院分区：
文献类型：
--
作者：
Wei YJ;Chen C;Winterstein AG
Discontinuation of long-term opioid therapy (LTOT) has increased in recent years. Yet, it is unclear whether this trend extends to patients with Alzheimer disease and related dementia (ADRD), a population with high prevalence of undertreated pain. Medicare data from 2011 to 2018 were analyzed to compare trends in use and discontinuation of LTOT (at least 3 months) between 162,099 patients with and 952,475 patients without ADRD who had chronic noncancer pain. Outcome measures were annual proportions of: (1) patients who received LTOT and (2) LTOT users who subsequently discontinued opioids for 30, 60, or ≥90 days during 12-month follow-up. All analyses were performed in 2021. Use of LTOT decreased from 2011 to 2017 in both the ADRD and non-ADRD groups. In LTOT users, discontinuation of opioids for 30, 60, and ≥90 days increased by 8% (95% CI=1.04, 1.12, p<0.001), 13% (95% CI=1.06, 1.20, p<0.001), and 18% (95% CI=1.10, 1.28, p<0.001), respectively, between 2011 and 2017 among patients with ADRD, whereas the proportion was largely declining or unchanged among patients without ADRD. Differences in LTOT discontinuation by ADRD status widened over time (p<0.01 for interaction). Discontinuation of LTOT was consistently higher in patients with ADRD than those with non-ADRD, with the gap between the 2 groups widening over time. Reasons for these differences and the risk–benefit of increased LTOT discontinuation among patients with ADRD warrant further investigation.
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作者：
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Miles, S