HEAT LOSS RESPONSES AND BLOCKADE OF PROSTAGLANDIN E2-INDUCED THERMOGENESIS ELICITED BY α1-ADRENERGIC ACTIVATION IN THE ROSTROMEDIAL PREOPTIC AREA
HEAT LOSS RESPONSES AND BLOCKADE OF PROSTAGLANDIN E2-INDUCED THERMOGENESIS ELICITED BY α1-ADRENERGIC ACTIVATION IN THE ROSTROMEDIAL PREOPTIC AREA
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DOI：
10.1016/j.neuroscience.2009.05.030
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发表时间：
2009-09-15
期刊：
影响因子：
3.3
通讯作者：
Osaka, T.
中科院分区：
文献类型：
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作者：
Osaka, T.
单侧微量注射去甲肾上腺素（NA），而不是溶剂溶液，到rostromedial视前区（POA）引起的同时增加皮肤温度的尾巴和脚底和全身的O-2消耗率，心率和结肠温度的下降，在氯醛糖麻醉大鼠，这表明一个协调的增加，在热损失和减少产热。除了代谢和心动过缓反应外，这些反应的幅度在1-100 pmol范围内呈剂量依赖性增加。微量注射40 pmol甲氧胺（一种α（1）肾上腺素能激动剂）也能引起类似的低温反应，但可乐定（一种α（2）肾上腺素能激动剂）或异丙肾上腺素（一种β肾上腺素能激动剂）则不能。显微注射NA引起低温反应的部位在终板血管器附近，包括正中视前核，而没有热或代谢反应时，NA被显微注射到外侧POA或内侧POA的尾部。微量注射130 fmol前列腺素（PG）E-2到NA敏感的网站总是引起产热，心动过速，和高热反应。此外，PGE（2）诱导的发热反应在相同部位预先给予NA后大大减弱。这些结果表明，在吻内侧POA NA发挥α（1）-肾上腺素受体介导的降温作用，并对抗前列腺素E（2）诱导的发热。(C)2009年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The unilateral microinjection of noradrenaline (NA), but not vehicle solution, into the rostromedial preoptic area (POA) elicited simultaneous increases in cutaneous temperatures of the tail and sole of the foot and decreases in the whole-body O-2 consumption rate, heart rate, and colonic temperature in urethane-chloralose-anesthetized rats, suggesting a coordinate increase in heat loss and decrease in heat production. The magnitude of these responses increased dose-dependently over the range of 1-100 pmol except for the metabolic and bradycardic responses. Similar hypothermic responses were elicited by the microinjection of 40 pmol methoxamine (an alpha(1)-adrenergic agonist), but not by that of clonidine (an alpha(2)-agonist) or isoproterenol (a beta-agonist). Sites at which microinjection of NA elicited hypothermic responses were in the vicinity of the organum vasculosum of the lamina terminalis including the median preoptic nucleus, whereas no thermal or metabolic response was elicited when NA was microinjected into the lateral POA or caudal part of the medial POA. The microinjection of 130 fmol prostaglandin (PG) E-2 into the NA-sensitive site always elicited thermogenic, tachycardic, and hyperthermic responses. Furthermore, the PGE(2)-induced febrile responses were greatly attenuated by prior administration of NA at the same site. These results demonstrate that NA in the rostromedial POA exerts alpha(1)-adrenoceptor-mediated hypothermic effects and opposes PGE(2)-induced fever. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.