SYNTHETIC INHIBITORS OF TRYPSIN, PLASMIN, KALLIKREIN, THROMBIN, C1 R BAR, AND C1 ESTERASE
SYNTHETIC INHIBITORS OF TRYPSIN, PLASMIN, KALLIKREIN, THROMBIN, C1 R BAR, AND C1 ESTERASE
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DOI：
10.1016/0005-2744(77)90097-3
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发表时间：
1977-01-01
期刊：
影响因子：
--
通讯作者：
FUJII, S
中科院分区：
文献类型：
--
作者：
TAMURA, Y;HIRADO, M;FUJII, S
p-Carbethoxyphenyl .epsilon。制备了-鸟嘌呤己酸酯和对-（p " -鸟嘌呤苯甲酰氧基）-苯基衍生物，考察了它们对牛胰蛋白酶、人纤溶酶、血浆钾化酶、凝血酶、C1.hivin的抑制作用。检测r和C1酯酶。在所测试的抑制剂中，对硝基苯基对”-胍基苯甲酸酯、N，N-二甲氨基对-（p”-胍基苯甲酰氧基）乙二醇酸盐和N，N-二甲氨基对-（p”-胍基苯甲酰氧基）苯甲氧基乙二醇酸盐是胰蛋白酶、纤溶酶、血浆钾激肽和凝血酶最有效的抑制剂，它们对C1.hivin的溶脂活性有较强的抑制作用。r和C1酯酶。
p-Carbethoxyphenyl .epsilon.-guanidinocaproate and p-(p''-guanidinobenzoyloxy)-phenyl derivatives were prepared, and their inhibitory effects on bovine trypsin, human plasmin, plasma kallikrein, thrombin, C1.hivin.r and C1 esterase were examined. Among various inhibitors tested, p-nitrophenyl p''-guanidinobenzoate, N,N-dimethylamino p-(p''-guanidinobenzoyloxy) glycolate and N,N-dimethylamino p-(p''-guanidinobenzoyloxy)-benzilcarbonyloxy glycolate were the most effective inhibitors of trypsin, plasmin, plasma kallikrein and thrombin, and they strongly inhibited the esterolytic activities of C1.hivin.r and C1 esterase.