Is season of birth a risk factor for attention-deficit hyperactivity disorder?
Is season of birth a risk factor for attention-deficit hyperactivity disorder?
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出生季节是注意力缺陷多动障碍的危险因素吗？
DOI：
10.1097/00004583-199611000-00015
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Faraone,SV
中科院分区：
文献类型：
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作者：
Mick,E;Biederman,J;Faraone,SV
目的探讨注意缺陷多动障碍（ADHD）儿童出生模式的季节性变化，并与一组正常对照儿童比较，探讨ADHD儿童的共病、家庭关系和学习障碍等问题。ADHD儿童被分层的存在共病精神疾病，学习障碍，ADHD的家族史，和Logistic回归被用来估计相对risk.STSTSTNo统计学上的主要影响，出生季节的ADHD和对照组儿童的比较中观察到。然而，9月出生的ADHD儿童有学习障碍（比值比= 5.4）和ADHD儿童没有精神科合并症（比值比= 4.5）的显着影响。一个趋势也注意到冬季出生的ADHD儿童学习障碍，没有精神科合并症，积极的家族史ADHDM.CONCLUSIONSSThese初步结果表明，可能有一个季节性模式的出生亚型的ADHD。如果出生季节作为季节性介导的病毒感染的时间代理，它可能会导致ADHD的病因学和病理生理学的更好的理解。
OBJECTIVETo investigate seasonal variations in the birth patterns of children with attention-deficit hyperactivity disorder (ADHD) in reference to a group of normal control children, attending to issues of comorbidity, familiality, and learning disability.METHODSubjects were boys with DSM-III-R ADHD (n = 140) and normal controls (n = 120). The ADHD children were stratified by the presence of comorbid psychiatric disorders, learning disability, and family history of ADHD, and logistic regression was used to estimate relative risks.RESULTSNo statistically major effect for season of birth was observed in the comparison of ADHD and control children. However, significant effects were found for September births for ADHD children with learning disability (odds ratio = 5.4) and for ADHD children without psychiatric comorbidity (odds ratio = 4.5). A trend was also noted for winter births in ADHD children with learning disabilities, no psychiatric comorbidity, and positive family history for ADHD.CONCLUSIONSThese preliminary results suggest that there may be a seasonal pattern of birth for subtypes of ADHD. If season of birth serves as a proxy for the timing of seasonally mediated viral infections, it may lead to a greater understanding of the etiology and pathophysiology of ADHD.