β‐ADRENOCEPTOR BLOCKING DRUGS AND ISOPRENALINE: CENTRAL EFFECTS ON CARDIOVASCULAR PARAMETERS
β‐ADRENOCEPTOR BLOCKING DRUGS AND ISOPRENALINE: CENTRAL EFFECTS ON CARDIOVASCULAR PARAMETERS
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β-肾上腺素受体阻滞药物和异丙肾上腺素：对心血管参数的中枢作用
DOI：
10.1111/j.1476-5381.1979.tb07842.x
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发表时间：
1979
影响因子：
7.3
通讯作者：
J. Wepierre
中科院分区：
文献类型：
--
作者：
Y. Cohen;A. Lindenbaum;M. Midol‐monnet;D. Porquet;J. Wepierre
1侧脑室注射（+）-和（-）-普萘洛尔（100 μg）、吲哚洛尔（100 μg）和异丙肾上腺素（1和4 μg）的中枢兴奋活性。在用氨基甲酸乙酯和氯醛糖麻醉的大鼠中研究。测量血压、心输出量和心率，计算收缩期每搏输出量和外周血管阻力。2（+）-和（-）-普萘洛尔和吲哚洛尔诱导血压下降，但（+）-普萘洛尔活性较低。（-）-普萘洛尔降低心率的作用大于（+）-普萘洛尔或（-）-吲哚洛尔。（-）-普萘洛尔和吲哚洛尔组的收缩期每搏输出量下降幅度大于（+）-普萘洛尔组。外周血管阻力降低至相同水平，但时间进程不同，（-）-普萘洛尔的作用时间长于（+）-普萘洛尔和吲哚洛尔。3异丙肾上腺素引起扩张作用，心输出量和心率增加，收缩期每搏输出量保持稳定，但外周血管阻力显著降低。这些结果表明，不同的中枢调节中心参与了心脏功能和外周血管张力的控制。
1 The central hypotensive activity of (+)‐ and (—)‐propranolol (100 μg), pindolol (100 μg) and isoprenaline (1 and 4 μg) injected intracerebroventricularly (i.c.v.) was studied in rats anaesthetized with urethane and chloralose. Blood pressure, cardiac output and heart rate were measured; systolic stroke volume and peripheral vascular resistance were calculated. 2 (+)‐ and (—)‐Propranolol and pindolol induced a fall of blood pressure but (+)‐propranolol was less active. The heart rate was reduced more by (—)‐propranolol than by (+)‐propranolol or (—)‐pindolol. The decrease of systolic stroke volume was greater for (—)‐propranolol and pindolol than for (+)‐propranolol. Peripheral vascular resistance was reduced to the same level but with different time courses, (—)‐propranolol having a longer effect than (+)‐propranolol and pindolol. 3 Isoprenaline induced a hypotensive effect, while cardiac output and heart rate increased; the systolic stroke volume remained stable but peripheral vascular resistance was significantly decreased. 4 These results suggest that different central regulatory centres are involved in the control of cardiac function and peripheral vascular tone.