Metabolic syndrome X: a review.
Metabolic syndrome X: a review.
复制标题
代谢综合征 X：回顾。
DOI：
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发表时间：
2000
影响因子：
6.2
通讯作者：
E. Levy
中科院分区：
文献类型：
--
作者：
O. Tímár;F. Sestier;E. Levy
代谢综合征X是一种多方面的综合征，经常发生在一般人群中。男性比女性更常见。工业化国家的成年人口中有很大一部分患上代谢综合征，这是由遗传、激素和生活方式因素如肥胖、缺乏运动和某些营养过剩引起的。这种疾病的特征在于胰岛素抵抗和高胰岛素血症的聚集，并且通常与血脂异常（致动脉粥样硬化的血浆脂质谱）、原发性高血压、腹部（内脏）肥胖、葡萄糖耐受不良或非胰岛素依赖型糖尿病以及心血管事件的增加的风险相关。在代谢综合征X中还发现凝血功能障碍（1型纤溶酶原激活物抑制物和纤维蛋白原水平升高）、高尿酸血症和微量白蛋白尿。本文综述了目前的知识异常，这种综合征。每个危险因素进行审查，并讨论了潜在的诊断标准和治疗目标。由于代谢综合征X患者积累了心脏危险因素，因此在诊断和治疗方面应给予特别关注。
Metabolic syndrome X is a multifaceted syndrome, which occurs frequently in the general population. It is more common in men than in women. A large segment of the adult population of industrialized countries develops the metabolic syndrome, produced by genetic, hormonal and lifestyle factors such as obesity, physical inactivity and certain nutrient excesses. This disease is characterized by the clustering of insulin resistance and hyperinsulinemia, and is often associated with dyslipidemia (atherogenic plasma lipid profile), essential hypertension, abdominal (visceral) obesity, glucose intolerance or noninsulin-dependent diabetes mellitus and an increased risk of cardiovascular events. Abnormalities of blood coagulation (higher plasminogen activator inhibitor type 1 and fibrinogen levels), hyperuricemia and microalbuminuria have also been found in metabolic syndrome X. This review summarizes the present knowledge of abnormalities in this syndrome. Each risk factor is reviewed, and potential criteria for diagnosis and therapeutic targets are discussed. Because patients with metabolic syndrome X accumulate cardiac risk factors, they should be given special attention in terms of diagnosis and treatment.