Role of Toll like receptor signaling pathway in ischemic coronary artery disease
Role of Toll like receptor signaling pathway in ischemic coronary artery disease
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DOI：
10.2741/3183
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发表时间：
2008-05-01
影响因子：
3.1
通讯作者：
Nakamura, Motoyuki
中科院分区：
文献类型：
--
作者：
Satoh, Mamoru;Ishikawa, Yuh;Nakamura, Motoyuki
炎症过程在缺血性冠状动脉疾病（CAD）中起着重要的作用，无论是在动脉粥样硬化的病因学上还是在CAD的病理生理上。特别是，慢性炎症在冠状动脉斑块不稳定和随后的闭塞性血栓形成中起关键作用。因此，阐明CAD发病机制中免疫应答激活的机制是很重要的。目前，在哺乳动物物种中已经报道了10种toll样受体（TLRs），这些受体似乎识别控制先天免疫反应的不同病原体相关分子模式。在最近的研究中，两种形式的人类TLR （TLR2和TLR4）的信号被证明参与了CAD的发病机制，在冠状动脉粥样硬化的进展和对外来病原体和内源性炎症配体的免疫反应之间建立了关键联系。更好地了解TLR信号可能为CAD的治疗提供新的药物。现就缺血性冠状动脉疾病的发病机制与TLR系统的关系作一综述。
Inflammatory process plays a fundamental role in ischemic coronary artery disease (CAD) in terms of both the etiology of atherosclerosis and the pathophysiology of CAD. In particular, chronic inflammation plays a key role in coronary artery plaque instability and subsequent occlusive thrombosis. It is therefore important to clarify the mechanism underlying the activation of the immune response in the pathogenesis of CAD. Currently 10 toll-like receptors (TLRs) have been reported in mammalian species, and these appear to recognize distinct pathogen-associated molecular patterns controlling innate immune responses. In recent studies, signaling of two forms of human TLR (TLR2 and TLR4) has been shown to be involved in the pathogenesis of CAD, establishing a key link between the progression of coronary atherosclerosis and immune response to both foreign pathogens and endogenously generated inflammatory ligands. A better understanding of TLR signal may provide a novel therapeutic agent for the treatment of CAD. This review summarizes the relationship between the pathogenesis of ischemic coronary artery disease and the human TLR system.