11β-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess
11β-Hydroxysteroid Dehydrogenase and the Syndrome of Apparent Mineralocorticoid Excess
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DOI：
10.1210/edrv.18.1.0288
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发表时间：
1997-02
影响因子：
20.3
通讯作者：
P. White;T. Mune;T. Mune;Anil K. Agarwal
中科院分区：
文献类型：
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作者：
P. White;T. Mune;T. Mune;Anil K. Agarwal
一、简介二、皮质醇代谢的生物化学三、盐皮质激素受体功能A.醛固酮的作用B.盐皮质激素受体的结构和功能C.假设：11-HSD保护盐皮质激素受体的功能IV.11-HSD的功能丧失A.明显的盐皮质激素过多综合症(AME)B.甘草中毒C.异位ACTH综合征D.高血压E.相关情况V.11-HSD的功能作用C.肝脏B.肾脏和其他盐皮质激素靶组织C.脑D.循环系统E.皮肤F.卵巢G.胎盘H.11-HSD的(肝脏)同工酶A.术语B.生物化学C.分子生物学D.表达E.缺乏与AME或11-还原酶缺乏症相关的症状VII.11-HSD的第二型(肾脏)同工酶A.生物化学B.分子生物学C.表达D.在所有AME患者中均检测到HSD11B2的突变。
I. Introduction II. Biochemistry of Cortisol Metabolism III. Mineralocorticoid Receptor Function A. Actions of aldosterone B. Structure and function of the mineralocorticoid receptor C. Hypothesis: 11-HSD protects the mineralocorticoid receptor IV. Loss of Function of 11-HSD A. Syndrome of apparent mineralocorticoid excess (AME) B. Licorice intoxication C. Ectopic ACTH syndrome D. Essential hypertension E. Related conditions V. Functional Roles of 11-HSD A. Liver B. Kidney and other mineralocorticoid target tissues C. Brain D. Circulatory system E. Skin F. Ovary G. Placenta H. Other fetal tissues VI. The Type I (Liver) Isozyme of 11-HSD A. Terminology B. Biochemistry C. Molecular biology D. Expression E. Lack of involvement in the syndromes of AME or 11-reductase deficiency VII. The Type 2 (Kidney) Isozyme of 11-HSD A. Biochemistry B. Molecular biology C. Expression D. Mutations in HSD11B2 are detected in all patients with AME VIII. Summary\.