Periodontal condition in Japanese coronary heart disease patients: A comparison between coronary and non-coronary heart diseases
Periodontal condition in Japanese coronary heart disease patients: A comparison between coronary and non-coronary heart diseases
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DOI：
10.1111/jre.12626
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发表时间：
2019-06-01
影响因子：
3.5
通讯作者：
Isobe, Mitsuaki
中科院分区：
文献类型：
--
作者：
Aoyama, Norio;Kobayashi, Naho;Isobe, Mitsuaki
目的探讨日本人群牙周细菌负荷与冠心病的关系。背景许多流行病学报告表明牙周炎是冠心病的危险因素，然而，日本冠心病患者的牙周细菌和牙周状况的影响尚不清楚。方法我们研究了2012年5月至2015年8月在东京医科齿科大学医院接受治疗的897例心血管疾病患者。根据年龄和是否存在冠心病将受试者分为六组（46-60岁冠心病组（n = 56）：YC组，61-70岁冠心病组（n = 106）：MC组，70岁以上冠心病组（n = 177）：EC组，46-60岁非冠心病组（n = 152）：YN组，61-70岁无CHD组（n = 216）：MN组，70岁以上无CHD组（n = 190）：EN组。结果MC组和EC组患者的牙周袋深度均较YN组深（P < 0.05），但YC组与MC组和EC组的牙周袋深度差异无统计学意义。与EN组相比，EC组许多受试者的抗牙龈卟啉单胞菌和抗中间普氏菌抗体较高（P < 0.05）。冠心病患者的口腔状况普遍比非冠心病患者差。老年冠心病患者血清抗牙龈卟啉单胞菌抗体和抗中间普氏菌抗体水平高于非冠心病患者。结论与非冠心病患者相比，日本冠心病患者的牙周感染增加。
Objective The aim of this clinical trial was to assess the relationship between periodontal bacterial burden and coronary heart disease (CHD) in Japanese population. Background Many epidemiological reports suggest that periodontitis is a risk factor for CHD; however, the influence of each periodontal bacterium and periodontal condition in Japanese CHD patients is unclear. Methods We studied 897 patients with cardiovascular diseases in Tokyo Medical and Dental University Hospital from May 2012 to August 2015. The subjects were divided into six groups according to age and the existence of CHD (46-60 years with CHD (n = 56): Group YC, 61-70 years with CHD (n = 106): Group MC, over 70 years with CHD (n = 177): Group EC, 46-60 years without CHD (n = 152): Group YN, 61-70 years without CHD (n = 216): Group MN, and over 70 years without CHD (n = 190): Group EN). Results We found that the patients in Groups MC and EC had deeper periodontal pocket compared to the patients in Group YN (P < 0.05), although there was no statistical difference of pocket depth between Group YC and Groups MC and EC. Many subjects in Group EC had high anti-Porphyromonas gingivalis and anti-Prevotella intermedia antibodies in comparison to Group EN (P < 0.05). The CHD patients generally had worse oral condition than the non-CHD patients. Elderly with CHD had a higher level of serum anti-Porphyromonas gingivalis antibody and anti-Prevotella intermedia antibody than those without CHD. Conclusion Increased periodontal infection was found in Japanese CHD patients compared to non-CHD patients.