Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes.
Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes.
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使用关键发育基因对胰腺β细胞进行直接重编程。
DOI：
10.1007/s40139-015-0068-0
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发表时间：
2015
影响因子：
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通讯作者：
Zhou,Qiao
中科院分区：
文献类型：
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作者：
Cavelti-Weder,Claudia;Li,Weida;Zumsteg,Adrian;Stemann,Marianne;Yamada,Takatsugu;Bonner-Weir,Susan;Weir,Gordon;Zhou,Qiao
直接重编程是再生医学的一种有前途的方法，其中一种细胞类型直接转化为另一种细胞类型，而不经历多能或多能阶段。这种重编程方法已被广泛探索用于从非β细胞产生功能性胰岛素分泌细胞，目的是开发用于治疗缺乏足够内源性β细胞的糖尿病患者的新型细胞疗法。这种转化研究的一种常见方法是引入在控制β细胞发育和维持中很重要的关键调节剂。在这篇综述中，我们将总结β细胞重编程领域的最新进展，并讨论创造功能和持久的β细胞的挑战。
Direct reprogramming is a promising approach for regenerative medicine whereby one cell type is directly converted into another without going through a multipotent or pluripotent stage. This reprogramming approach has been extensively explored for the generation of functional insulin-secreting cells from non-beta-cells with the aim of developing novel cell therapies for the treatment of people with diabetes lacking sufficient endogenous beta-cells. A common approach for such conversion studies is the introduction of key regulators that are important in controlling beta-cell development and maintenance. In this review, we will summarize the recent advances in the field of beta-cell reprogramming and discuss the challenges of creating functional and long-lasting beta-cells.