Stem Cell Research in Stroke How Far From the Clinic?
Stem Cell Research in Stroke How Far From the Clinic?
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DOI：
10.1161/strokeaha.110.599654
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发表时间：
2011-08-01
期刊：
影响因子：
8.3
通讯作者：
Kokaia, Zaal
中科院分区：
文献类型：
--
作者：
Lindvall, Olle;Kokaia, Zaal
基于干细胞的方法作为中风后恢复功能的潜在新型治疗方法有很大的希望。在动物模型中的研究已经表明，干细胞移植可以通过替代神经元或通过营养作用、调节炎症、促进血管生成、髓鞘再生和轴突可塑性以及神经保护来改善功能。内源性神经干细胞也是潜在的治疗靶点，因为它们在中风后产生新的神经元。临床试验正在进行中，但目前还没有经过证实的基于干细胞的中风治疗方法。需要进行临床前研究和临床研究来优化干细胞在中风中的治疗益处并最大限度地降低其风险。（中风。2011;42：2369-2375）。
Stem cell-based approaches hold much promise as potential novel treatments to restore function after stroke. Studies in animal models have shown that stem cell transplantation can improve function by replacing neurons or by trophic actions, modulation of inflammation, promotion of angiogenesis, remyelination and axonal plasticity, and neuroprotection. Endogenous neural stem cells are also potential therapeutic targets because they produce new neurons after stroke. Clinical trials are ongoing but there is currently no proven stem cell-based therapy for stroke. Preclinical studies and clinical research will be needed to optimize the therapeutic benefit and minimize the risks of stem cells in stroke. (Stroke. 2011;42:2369-2375.)