PP2A as a master regulator of the cell cycle.
PP2A as a master regulator of the cell cycle.
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DOI：
10.3109/10409238.2016.1143913
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发表时间：
2016-05
影响因子：
6.5
通讯作者：
Xing Y
中科院分区：
文献类型：
--
作者：
Wlodarchak N;Xing Y
蛋白磷酸酶2A（PP2A）在细胞周期调控中起着重要的多方面作用。已知它可以使细胞周期中涉及的300多种底物脱磷酸化，调节几乎所有主要途径和细胞周期检查点。PP2A通过形成结构上不同的全酶家族参与这种不同的过程，这些全酶家族在空间和时间上由特定的调节剂调节。本文综述了PP2A对wnt、mTOR和MAP激酶三种细胞信号通路的调控，以及PP2A对G1→S转换、DNA合成和有丝分裂起始的调控。这些过程对于细胞的正常存活和增殖都至关重要，并且在癌症和其他疾病中经常被解除管制。
Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell cycle, regulating almost all major pathways and cell cycle checkpoints. PP2A is involved in such diverse processes by the formation of structurally distinct families of holoenzymes, which are regulated spatially and temporally by specific regulators. Here, we review the involvement of PP2A in the regulation of three cell signaling pathways: wnt, mTOR and MAP kinase, as well as the G1→S transition, DNA synthesis and mitotic initiation. These processes are all crucial for proper cell survival and proliferation and are often deregulated in cancer and other diseases.