Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year.
Walking stabilizes cognitive functioning in Alzheimer's disease (AD) across one year.
复制标题
DOI：
10.1016/j.archger.2012.06.016
复制
发表时间：
2013-01
影响因子：
4
通讯作者：
Cotman CW
中科院分区：
文献类型：
--
作者：
Winchester J;Dick MB;Gillen D;Reed B;Miller B;Tinklenberg J;Mungas D;Chui H;Galasko D;Hewett L;Cotman CW
AD是一种公共卫生流行病，严重影响认知、情绪和日常活动；然而，一种类型的活动--锻炼--已被证明可以改变这些状态。因此，我们试图调查运动和情绪之间的关系，对来自加利福尼亚州的早期AD患者(N=104)进行为期一年的研究。患者完成了简易精神状态检查(MMSE)、老年抑郁量表(GDS)和幸福-罗斯痴呆量表(BRDRS)，而他们的照顾者则完成了耶鲁大学体力活动调查(Yale)、情绪状态简表(POMS)、神经精神病学问卷(NPI)和功能能力问卷(FAQ)。参与者中约有一半是女性，来自不同的种族(高加索人=69.8%；拉丁裔/拉美裔美国人=20.1%)。我们的结果表明，患者一般很少从事体力活动，他们的总体活动水平随着时间的推移而下降，这与整体认知(例如，MMSE总分)和情感/情绪(例如，POMS分数)的变化相伴随。根据耶鲁大学的概况，患者被分析为活动组和久坐组，积极参与者每周参加步行活动，超过1年。在这里，久坐的患者的MMSE得分显著下降，而活跃的患者总体认知能力下降的程度有所减弱。重要的是，在活动期AD患者中，那些每周步行超过2小时的人在MMSE得分上有显著改善。有必要进行结构化的临床试验，寻求增加AD患者从事步行活动的时间，并评估对大脑有益的影响的性质和范围。
AD is a public health epidemic, which seriously impacts cognition, mood and daily activities; however, one type of activity, exercise, has been shown to alter these states. Accordingly, we sought to investigate the relationship between exercise and mood, in early-stage AD patients (N = 104) from California, over a 1-year period. Patients completed the Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS), and Blessed-Roth Dementia Rating Scale (BRDRS), while their caregivers completed the Yale Physical Activity Survey (YALE), Profile of Mood States (POMS), the Neuropsychiatric Inventory (NPI) and Functional Abilities Questionnaire (FAQ). Approximately half of the participants were female, from a variety of ethnic groups (Caucasian = 69.8%; Latino/Hispanic Americans = 20.1%). Our results demonstrated that the patients spent little time engaged in physical activity in general, their overall activity levels decreased over time, and this was paired with a change in global cognition (e.g., MMSE total score) and affect/mood (e.g., POMS score). Patients were parsed into Active and Sedentary groups based on their Yale profiles, with Active participants engaged in walking activities, weekly, over 1 year. Here, Sedentary patients had a significant decline in MMSE scores, while the Active patients had an attenuation in global cognitive decline. Importantly, among the Active AD patients, those individuals who engaged in walking for more than 2 h/week had a significant improvement in MMSE scores. Structured clinical trials which seek to increase the amount of time AD patients were engaged in walking activities and evaluate the nature and scope of beneficial effects in the brain are warranted.
登录
查看更多内容
影响因子：
5.3
作者：
Adlard, PA;Perreau, VM;Cotman, CW
通讯作者：
Cotman, CW
影响因子：
--
作者：
Antunes, Hanna Karen Moreira;Stella, Sérgio Garcia;Mello, Marco Túlio de
通讯作者：
Mello, Marco Túlio de
影响因子：
3.1
作者：
Kramer, AF;Colcombe, SJ;Webb, AG
通讯作者：
Webb, AG
影响因子：
1.2
作者：
Albani, C;Gunzelmann, T;Brähler, E
通讯作者：
Brähler, E
影响因子：
7
作者：
Larson EB
通讯作者：
Larson EB