Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination.
Induction of ICOS+CXCR3+CXCR5+ TH cells correlates with antibody responses to influenza vaccination.
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DOI：
10.1126/scitranslmed.3005191
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发表时间：
2013-03-13
影响因子：
17.1
通讯作者：
Ueno H
中科院分区：
文献类型：
--
作者：
Bentebibel SE;Lopez S;Obermoser G;Schmitt N;Mueller C;Harrod C;Flano E;Mejias A;Albrecht RA;Blankenship D;Xu H;Pascual V;Banchereau J;Garcia-Sastre A;Palucka AK;Ramilo O;Ueno H
季节性流感疫苗可保护60%至90%的健康年轻人免受流感感染。导致诱导保护性抗体应答的免疫学事件在人类中仍然知之甚少。我们确定了季节性流感疫苗接种后与保护性抗体应答相关的CD 4 + T细胞类型。施用三价裂解病毒流感疫苗诱导表达ICOS的CD 4 + T细胞暂时增加，其在第7天达到峰值，浆母细胞也是如此。ICOS的诱导主要限于共表达趋化因子受体CXCR 3和CXCR 5的CD 4 + T细胞，CXCR 3和CXCR 5是循环记忆T滤泡辅助细胞的亚群。这些ICOS+ CXCR 3 + CXCR 5 + CD 4 + T细胞中高达60%对流感抗原具有特异性，并在抗原刺激后表达白细胞介素-2（IL-2）、IL-10、IL-21和干扰素-γ。血液中ICOS+ CXCR 3 + CXCR 5 + CD 4 + T细胞的增加与预先存在的抗体滴度的增加相关，但与诱导的一次抗体应答无关。一致地，纯化的ICOS+ CXCR 3 + CXCR 5 + CD 4 + T细胞有效地诱导记忆B细胞，但不能诱导幼稚B细胞分化为离体产生流感特异性抗体的浆细胞。因此，血液ICOS+ CXCR 3 + CXCR 5 + CD 4 + T细胞的出现与季节性流感疫苗接种后记忆B细胞产生的保护性抗体应答的发展相关。
Seasonal influenza vaccine protects 60 to 90% of healthy young adults from influenza infection. The immunological events that lead to the induction of protective antibody responses remain poorly understood in humans. We identified the type of CD4+ T cells associated with protective antibody responses after seasonal influenza vaccinations. The administration of trivalent split-virus influenza vaccines induced a temporary increase of CD4+ T cells expressing ICOS, which peaked at day 7, as did plasmablasts. The induction of ICOS was largely restricted to CD4+ T cells co-expressing the chemokine receptors CXCR3 and CXCR5, a subpopulation of circulating memory T follicular helper cells. Up to 60% of these ICOS+CXCR3+CXCR5+CD4+ T cells were specific for influenza antigens and expressed interleukin-2 (IL-2), IL-10, IL-21, and interferon-γ upon antigen stimulation. The increase of ICOS+CXCR3+CXCR5+CD4+ T cells in blood correlated with the increase of preexisting antibody titers, but not with the induction of primary antibody responses. Consistently, purified ICOS+CXCR3+CXCR5+CD4+ T cells efficiently induced memory B cells, but not naïve B cells, to differentiate into plasma cells that produce influenza-specific antibodies ex vivo. Thus, the emergence of blood ICOS+CXCR3+CXCR5+CD4+ T cells correlates with the development of protective antibody responses generated by memory B cells upon seasonal influenza vaccination.
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影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
DOI：
10.1126/science.1176676
发表时间：
2009-08-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Nurieva RI;Chung Y;Martinez GJ;Yang XO;Tanaka S;Matskevitch TD;Wang YH;Dong C
通讯作者：
Dong C
DOI：
10.1084/jem.20102065
发表时间：
2011-07-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lee SK;Rigby RJ;Zotos D;Tsai LM;Kawamoto S;Marshall JL;Ramiscal RR;Chan TD;Gatto D;Brink R;Yu D;Fagarasan S;Tarlinton DM;Cunningham AF;Vinuesa CG
通讯作者：
Vinuesa CG
影响因子：
4
作者：
Ma, Cindy S.;Suryani, Santi;Tangye, Stuart G.
通讯作者：
Tangye, Stuart G.
CXCR3在parainfluenza病毒感染期间将抗原特异性效应子CD4+ T细胞迁移到肺部。
影响因子：
4.4
作者：
Kohlmeier, Jacob E.;Cookenham, Tres;Miller, Shannon C.;Roberts, Alan D.;Christensen, Jan P.;Thomsen, Allan R.;Woodland, David L.
通讯作者：
Woodland, David L.