The multifaceted biology of plasmacytoid dendritic cells.
The multifaceted biology of plasmacytoid dendritic cells.
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DOI：
10.1038/nri3865
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Colonna M
中科院分区：
文献类型：
--
作者：
Swiecki M;Colonna M
浆细胞样树突状细胞（Plasmacytoid dendritic cells，pDC）是一种独特的树突状细胞亚群，其专门产生I型干扰素（IFN）。pDC促进抗病毒免疫应答，并且与以I型IFN特征为特征的自身免疫性疾病的发病机制有关。然而，pDC也可以诱导致耐受性免疫应答。本文综述了pDC生物学领域的最新进展，重点是：调控pDC发育和功能的分子机制; pDC对病原体和内源性核酸的敏感途径; pDC在粘膜部位的功能;以及它们在感染、自身免疫和癌症中的作用。
Plasmacytoid dendritic cells (pDCs) are a unique dendritic cell subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune responses and have been implicated in the pathogenesis of autoimmune diseases characterized by a type I IFN signature. However, pDCs can also induce tolerogenic immune responses. Here, we review recent progress from the field of pDC biology, focusing on: the molecular mechanisms that regulate pDC development and functions; the pathways involved in their sensing of pathogens and endogenous nucleic acids; the function of pDCs at mucosal sites; and their roles in infections, autoimmunity and cancer.