Association of calf circumference with insulin resistance and non-alcohol fatty liver disease: the REACTION study.
Association of calf circumference with insulin resistance and non-alcohol fatty liver disease: the REACTION study.
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小腿围与胰岛素抵抗和非酒精性脂肪肝的关系：REACTION 研究
DOI：
10.1186/s12902-017-0176-4
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发表时间：
2017-05-30
影响因子：
2.7
通讯作者：
Su Q
中科院分区：
文献类型：
--
作者：
Zhang W;Yang Z;Niu Y;Li X;Zhu L;Lu S;Zhang H;Fan J;Ning G;Qin L;Su Q
非酒精性脂肪性肝病(NAFLD)的特点是无酗酒史的受试者肝脏脂质过度堆积。小腿围是下半身脂肪的代用指标，也是识别脂肪堆积的筛查方法。本研究的目的是检验小腿围与非酒精性脂肪肝的关系。方法对8850名中老年人进行横断面分析。非酒精性脂肪肝患者均行肝脏超声检查，无酗酒及其他肝病。结果男、女平均小腿围分别为35.7m m和34.6m m(P<； 0.001)。与最低的小腿围四分位数相比，调整了潜在的联合创始人后，最高四分位数的非酒精性脂肪肝的优势比为2.73(95%可信区间为2.34-3.19，P趋势与0.001)。小腿围与HOMA-IR、肝酶水平、甘油三酯呈显著正相关。此外，在超重和肥胖者(体重指数 ≥ 为24 kg/m2)中，小腿围与HOMA-IR和空腹胰岛素水平呈显著正相关，而在瘦人组(交互作用检验：胰岛素和HOMA-IR的P均小于0.001)中，小腿围与非酒精性脂肪肝的发病率和胰岛素抵抗的增加显著相关。
BackgroundThe feature of nonalcoholic fatty liver disease (NAFLD) is pathological excessive liver lipid accumulation of subjects who without history of alcohol abuse. Calf circumference is a proxy for lower-body fat and screening method for the identification of subjects with acatastatic lipid accumulation. The objective of this study was to examine the association between calf circumference and NAFLD.MethodsThe study was a cross-sectional analysis including 8850 middle-aged and elderly individuals. NAFLD was examined by hepatic ultrasound and without alcohol abuse and other liver diseases. Calf circumference was measured on the lower right leg at the point of maximal circumference.ResultsThe mean of calf circumference were 35.7 cm for male and 34.6 cm for female (P< 0.001), respectively. Compared with the lowest calf circumference quartile, the odds ratio for NAFLD in the highest quartile was 2.73 (95% CI 2.34-3.19,Ptrend<0.001) after adjusted for potential cofounders. There were also significant positive correlation between calf circumference and HOMA-IR, liver enzyme levels and triglycerides. In addition, we found significant positive correlation of calf circumference with the HOMA-IR and fasting insulin level in overweight and obese subjects (BMI ≥ 24 kg/m2) but not in lean subjects (test for interaction: P both less than 0.001 for insulin and HOMA-IR).ConclusionHigh calf circumference is significantly associated with elevated prevalence of NAFLD and increasing insulin resistance.