Enhanced metaboreflex sensitivity in hypertensive humans.
Enhanced metaboreflex sensitivity in hypertensive humans.
复制标题
高血压人群代谢反射敏感性增强。
DOI：
10.1007/s00421-008-0910-8
复制
发表时间：
2009
影响因子：
3
通讯作者：
Farquhar,WilliamB
中科院分区：
文献类型：
--
作者：
Sausen,MT;Delaney,EP;Stillabower,ME;Farquhar,WilliamB
运动加压反射(EPR)由机械反射和代谢反射组成，在自发性高血压大鼠中表现为过度活动。本研究的目的是利用运动后缺血(PEI)分离代谢性反射，并检测正常血压(NTN)和高血压(HTN)人群的血压反应。我们假设，与NTN成人相比，HTN患者运动后缺血诱导的血压维持作用更大。共招募15名NTN(65岁±1岁)和12名HTN(15岁±1岁)成人。每搏一搏的平均动脉压(MAP)无创测量(Fineter)。动态握力训练(DHE)3min，然后PEI 2min。采用不配对t检验来检验不同组间的差异。与静息基础值相比，高血压性糖尿病患者PEI期间MAP的变化大于非高血压性糖尿病患者(高血压病患者：Δ=9.12±13.3毫米汞柱，低血压性糖尿病患者：Δ=9.6±0.11毫米汞柱，P<；0.05)。这些数据表明，HTN患者具有增强的代谢性反射敏感性。
The exercise pressor reflex (EPR) is composed of the mechanoreflex and the metaboreflex and has been shown to be overactive in spontaneously hypertensive rats. The aim of the present study was to isolate the metaboreflex using post-exercise ischemia (PEI) and examine the BP response in normotensive (NTN) and hypertensive (HTN) humans. We hypothesize that the post-exercise ischemia-induced maintenance of BP will be greater in HTN when compared to NTN adults. A total of 15 NTN (65 ± 1 years) and 12 HTN (64 ± 1 years) adults were recruited. Beat-to-beat mean arterial pressure (MAP) was measured non-invasively (Finometer). Dynamic handgrip exercise (DHE) was performed for 3 min followed by 2 min of PEI. An unpairedttest was used to examine differences between groups. As compared to resting baseline values, the change in MAP during PEI was greater in HTN than NTN subjects (HTN: Δ = 12 ± 3 mmHg, NTN: Δ = 6 ± 1 mmHg,P< 0.05). These data suggest that HTN humans have enhanced metaboreflex sensitivity.