Oenothein B Suppresses Lipopolysaccharide (LPS)-Induced Inflammation in the Mouse Brain
Oenothein B Suppresses Lipopolysaccharide (LPS)-Induced Inflammation in the Mouse Brain
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DOI：
10.3390/ijms14059767
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发表时间：
2013-05-01
影响因子：
5.6
通讯作者：
Furukawa, Yoshiko
中科院分区：
文献类型：
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作者：
Okuyama, Satoshi;Makihata, Nahomi;Furukawa, Yoshiko
Oenothein B最近因其影响外周组织炎症反应的能力而被评估。在这项研究中，我们研究了它对全身炎症引起的中枢神经系统损伤的影响。为此，对ICR小鼠进行了腹腔注射(Ip)。脂多糖(LPS；1 mg/kg小鼠)剂量。Oenothein B灌胃给药后，可抑制(1)内毒素诱导的旷场行为异常；(2)抑制内毒素诱导的小鼠海马区和纹状体小胶质细胞的激活；(3)抑制内毒素诱导的小鼠海马区和纹状体环氧合酶-2的产生。这些结果表明，Oenothein B有能力在全身炎症期间减少大脑中的神经炎症。
Oenothein B has been recently evaluated for its ability to affect inflammatory responses in peripheral tissues. In this study, we examined its effect on the damage to the central nervous system due to systemic inflammation. For this purpose, ICR mice were injected with an intraperitoneal (i.p.) dose of lipopolysaccharide (LPS; 1 mg/kg mouse). When oenothein B was administered per os (p.o.), it suppressed (1) LPS-induced abnormal behavior in open field; (2) LPS-induced microglial activation in the hippocampus and striatum; and (3) LPS-induced cyclooxygenase (COX)-2 production in the hippocampus and striatum of these mice. These results suggest that oenothein B had the ability to reduce neuroinflammation in the brain during systemic inflammation.