Synthesis of 4-dihydroxyboryl-2-[18F] fluorophenylalanine with relatively high-specific activity
Synthesis of 4-dihydroxyboryl-2-[18F] fluorophenylalanine with relatively high-specific activity
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DOI：
10.1002/jlcr.600
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发表时间：
2002-07-01
影响因子：
1.8
通讯作者：
Solin, O
中科院分区：
文献类型：
--
作者：
Vähätalo, JK;Eskola, O;Solin, O
本文介绍了一种制备用于硼中子俘获治疗中正电子发射断层扫描研究的4-二羟基硼基-2-[F-18]氟苯丙氨酸（[F-18]FBPA）的替代方法。使用[F-18]F-至[F-18]F-2的靶后转化产生相对高比活度的亲电放射性氟。采用液相色谱-质谱检测法估计[F-18]FBPA的比放射性，并验证目标化合物化学鉴别的质量控制。[F-18]按照该方法生产的FBPA符合患者注射剂的药物质量要求。版权所有（C）2002约翰威利父子有限公司
An alternative procedure to produce 4-dihydroxyboryl-2-[F-18]fluorophenylalanine ([F-18]FBPA) for positron emission tomography studies in boron neutron capture therapy is described. Relatively high-specific activity electrophilic radiofluorine is produced using a post-target conversion of [F-18]F- to [F-18]F-2. Liquid chromatography with mass spectrometric detection is used to estimate the specific radioactivity of [F-18]FBPA and to verify the quality control for chemical identity of the target compound. [F-18]FBPA produced according to this method fulfilled the pharmaceutical quality requirements for an injection in patients. Copyright (C) 2002 John Wiley Sons, Ltd.