RS3PE syndrome presenting as vascular endothelial growth factor associated disorder
RS3PE syndrome presenting as vascular endothelial growth factor associated disorder
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DOI：
10.1136/ard.2004.032995
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发表时间：
2005-11-01
影响因子：
27.4
通讯作者：
Eguchi, K
中科院分区：
文献类型：
--
作者：
Arima, K;Origuchi, T;Eguchi, K
目的：检测缓解期血清阴性对称性滑膜凹陷性水肿症(RS3PE)患者激素治疗前后血清中各种细胞因子的浓度及MRI检测滑膜血管的情况。方法：采用酶联免疫吸附试验(EL ISA)检测3例RS3PE综合征患者血清中血管内皮生长因子(165)、肿瘤坏死因子α(TNFα)、白介素1β(IL1β)的水平。同时对26例健康志愿者、12例类风湿关节炎、10例系统性红斑狼疮、13例多发性肌炎/皮肌炎、13例血管炎综合征和6例混合性结缔组织病患者的血清标本进行分析。结果：活动期RS3PE综合征患者血清血管内皮生长因子浓度为2223.3(SD)2223.3(156.3)pg/ml，显著高于对照组。患者和对照组的肿瘤坏死因子α和白介素1β水平相似。激素治疗后关节滑膜血管增多和皮下水肿减少，同时血清VEGF165水平下降。结论：血管内皮生长因子促进了RS3PE综合征患者的滑膜炎症和血管通透性，提示RS3PE是一种与血管内皮生长因子相关的疾病。
Objectives: To characterise serum concentrations of various cytokines and detection by magnetic resonance imaging (MRI) of synovial hypervascularity in patients with remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome before and after corticosteroid treatment.Methods: Vascular endothelial growth factor(165) (VEGF(165)), tumour necrosis factor alpha (TNF alpha), and interleukin 1b (IL1 beta) were measured by enzyme linked immunosorbent assay (ELISA) in serum samples from three patients with RS3PE syndrome. As controls, serum samples from 26 healthy volunteers, 12 patients with rheumatoid arthritis, 10 patients with systemic lupus erythematosus, 13 patients with polymyositis/dermatomyositis, 13 patients with vasculitis syndrome, and 6 patients with mixed connective tissue disease were also analysed. Synovial hypervascularity of patients with RS3PE syndrome was estimated by rate of enhancement (E-rate) in a dynamic MRI study.Results: Serum concentrations of VEGF(165) (mean (SD) 2223.3 (156.3) pg/ml) were significantly higher in patients with active RS3PE syndrome than in controls before corticosteroid treatment. TNF alpha and IL1 beta levels were similar in patients and controls. Synovial hypervascularity in affected joints and subcutaneous oedema decreased during corticosteroid treatment, in parallel with the fall in serum VEGF165.Conclusions: VEGF promotes synovial inflammation and vascular permeability in patients with RS3PE syndrome, suggesting that RS3PE can be classified as a VEGF associated disorder.