Limited sex differences in response to "binge" smoked cocaine use in humans
Limited sex differences in response to "binge" smoked cocaine use in humans
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DOI：
10.1016/s0893-133x(98)00120-1
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发表时间：
1999-09-01
影响因子：
7.6
通讯作者：
Foltin, RW
中科院分区：
文献类型：
--
作者：
Evans, SM;Haney, M;Foltin, RW
对11名男性和9名女性反复吸食可卡因的主观和生理效应进行了比较。参与者连续两天每天抽两次50毫克的可卡因，每隔14分钟抽一次。男性和女性自我注射的可卡因剂量相似(分别为21.7和21.6)。最显著的性别差异是，在第一阶段的第六次可卡因剂量后，女性的可卡因血浆浓度(632.7 ng/ml比376.7 mg/ml)高于男性。在第一剂可卡因之后，女性报告称，她们在这一剂量上的花费明显低于男性(1.58美元对3.15美元)。尽管可卡因在每次服药后4分钟和最后一次服药后15分钟对男性和女性产生相似的影响，但女性的心率和血压仍然较高，但女性的“我想要可卡因”的评级低于男性。因此，吸烟的可卡因对男性和女性产生类似的急性主观影响，但对女性的心血管影响更长，可卡因的血浆浓度更高。(C)1999年美国神经精神药理学学院。爱思唯尔科学公司出版。
The subjective and physiological effects of repeated smoked cocaine self-administration were compared in 11 men and 9 women. Twice a day, on 2 consecutive days, participants smoked up to six 50-mg doses of cocaine base, at 14 min intervals. Men and women self-administered a similar number of cocaine doses (21.7 and 21.6, respectively). The most striking sex difference teas that women had higher cocaine plasma concentrations than men (632.7 ng/ml vs. 376.7 mg/ml) after the sixth cocaine dose of the first session. After the first cocaine dose, women reported that they would spend significantly less for the dose than men ($1.58 vs. $3.15). Although cocaine produced similar effects in men and women 4 min after each dose, 15 min after the last dose of the session, heart rate and blood pressure remained elevated in women, but ratings of "I want cocaine" were lower in women a compared to men. Thus, smoking cocaine produced similar acute subjective effects in men and women, but prolonged cardiovascular effects and higher cocaine plasma concentrations in women. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.