Testicular dysgenesis syndrome:: an increasingly common developmental disorder with environmental aspects
Testicular dysgenesis syndrome:: an increasingly common developmental disorder with environmental aspects
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DOI：
10.1093/humrep/16.5.972
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发表时间：
2001-05-01
影响因子：
6.1
通讯作者：
Main, KM
中科院分区：
文献类型：
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作者：
Skakkebæk, NE;Rajpert-De Meyts, E;Main, KM
最近有许多报告集中讨论男性生殖健康不利趋势的各个方面，例如睾丸癌发病率上升;精液质量低，而且可能下降;隐睾症和尿道下裂的发生率高，而且可能增加;对辅助生殖的需求明显增加。由于医学的专业化和出现症状的年龄不同，生殖问题过去常常由不同的专业群体，如儿科内分泌学家、泌尿科医生、男科医生和肿瘤学家分别进行分析。本文总结了现有的证据，支持一个新的概念，即精液质量差、睾丸癌、隐睾和尿道下裂是一个潜在的实体，睾丸发育不全综合征（TDS）的症状，实验和流行病学研究表明，TDS是胎儿期胚胎编程和性腺发育中断的结果，因此，我们建议未来关于男性生殖健康趋势的流行病学研究不应只关注一种症状，而应更全面，考虑TDS的各个方面，否则，可能丢失重要的生物信息。
Numerous reports have recently focused on various aspects of adverse trends in male reproductive health, such as the rising incidence of testicular cancer; low and probably declining semen quality; high and possibly increasing frequencies of undescended testis and hypospadias; and an apparently growing demand for assisted reproduction. Due to specialization in medicine and different ages at presentation of symptoms, reproductive problems used to be analysed separately by various professional groups, e,g, paediatric endocrinologists, urologists, andrologists and oncologists, This article summarizes existing evidence supporting a new concept that poor semen quality, testis cancer, undescended testis and hypospadias are symptoms of one underlying entity, the testicular dysgenesis syndrome (TDS), which may be increasingly common due to adverse environmental influences, Experimental and epidemiological studies suggest that TDS is a result of disruption of embryonal programming and gonadal development during fetal life, Therefore, we recommend that future epidemiological studies on trends in male reproductive health should not focus on one symptom only, but be more comprehensive and take all aspects of TDS into account, Otherwise, important biological information may be lost.