Reprogramming of Amino Acid Metabolism in Pancreatic Cancer: Recent Advances and Therapeutic Strategies.
Reprogramming of Amino Acid Metabolism in Pancreatic Cancer: Recent Advances and Therapeutic Strategies.
复制标题
DOI：
10.3389/fonc.2020.572722
复制
发表时间：
2020
影响因子：
4.7
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Xu R;Yang J;Ren B;Wang H;Yang G;Chen Y;You L;Zhao Y
胰腺导管腺癌（PDAC）是最致命的恶性肿瘤之一，预后极差。能量代谢重编程是癌症的一个新兴标志，与胰腺癌的肿瘤发生和发展有关。除了精心设计的增强糖酵解之外，近年来，研究氨基酸代谢重编程的作用也引起了人们的极大兴趣。由基因改变精心安排的氨基酸代谢重新布线导致胰腺癌的恶性特征，包括细胞增殖、侵袭、转移、血管生成和氧化还原平衡。在独特的低灌注和营养缺乏的肿瘤微环境 (TME) 中，癌细胞和基质成分之间的相互作用以及包括自噬和巨胞饮作用在内的挽救过程在满足代谢需求和支持 PDAC 生长方面发挥着关键作用。在这篇综述中，我们阐明了胰腺癌氨基酸代谢重编程的最新进展以及氨基酸代谢调节 PDAC 进展的机制，这将为开发有前景的治疗策略提供机会。
Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal malignancies with an extremely poor prognosis. Energy metabolism reprogramming, an emerging hallmark of cancer, has been implicated in the tumorigenesis and development of pancreatic cancer. In addition to well-elaborated enhanced glycolysis, investigating the role of reprogramming of amino acid metabolism has sparked great interests in recent years. The rewiring amino acid metabolism orchestrated by genetic alterations contributes to pancreatic cancer malignant characteristics including cell proliferation, invasion, metastasis, angiogenesis and redox balance. In the unique hypoperfused and nutrient-deficient tumor microenvironment (TME), the interactions between cancer cells and stromal components and salvaging processes including autophagy and macropinocytosis play critical roles in fulfilling the metabolic requirements and supporting growth of PDAC. In this review, we elucidate the recent advances in the amino acid metabolism reprogramming in pancreatic cancer and the mechanisms of amino acid metabolism regulating PDAC progression, which will provide opportunities to develop promising therapeutic strategies.
登录
查看更多内容
影响因子：
82.9
作者：
Davidson SM;Jonas O;Keibler MA;Hou HW;Luengo A;Mayers JR;Wyckoff J;Del Rosario AM;Whitman M;Chin CR;Condon KJ;Lammers A;Kellersberger KA;Stall BK;Stephanopoulos G;Bar-Sagi D;Han J;Rabinowitz JD;Cima MJ;Langer R;Vander Heiden MG
通讯作者：
Vander Heiden MG
DOI：
10.1126/science.aaw9872
发表时间：
2020-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badgley MA;Kremer DM;Maurer HC;DelGiorno KE;Lee HJ;Purohit V;Sagalovskiy IR;Ma A;Kapilian J;Firl CEM;Decker AR;Sastra SA;Palermo CF;Andrade LR;Sajjakulnukit P;Zhang L;Tolstyka ZP;Hirschhorn T;Lamb C;Liu T;Gu W;Seeley ES;Stone E;Georgiou G;Manor U;Iuga A;Wahl GM;Stockwell BR;Lyssiotis CA;Olive KP
通讯作者：
Olive KP
影响因子：
64.5
作者：
De Bock, Katrien;Georgiadou, Maria;Carmeliet, Peter
通讯作者：
Carmeliet, Peter
影响因子：
64.8
作者：
Dey P;Baddour J;Muller F;Wu CC;Wang H;Liao WT;Lan Z;Chen A;Gutschner T;Kang Y;Fleming J;Satani N;Zhao D;Achreja A;Yang L;Lee J;Chang E;Genovese G;Viale A;Ying H;Draetta G;Maitra A;Wang YA;Nagrath D;DePinho RA
通讯作者：
DePinho RA
影响因子：
5.9
作者：
Chakrabarti G;Moore ZR;Luo X;Ilcheva M;Ali A;Padanad M;Zhou Y;Xie Y;Burma S;Scaglioni PP;Cantley LC;DeBerardinis RJ;Kimmelman AC;Lyssiotis CA;Boothman DA
通讯作者：
Boothman DA