Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-Identical sibling.
Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-Identical sibling.
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DOI：
10.1056/nejm200006223422501
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发表时间：
2000-06-22
影响因子：
158.5
通讯作者：
Gluckman, E
中科院分区：
文献类型：
--
作者：
Rocha, V;Wagner, JE;Gluckman, E
背景资料：脐带血作为骨髓造血干细胞移植的替代品可能会降低移植物抗宿主病（GVHD）的风险。方法：我们研究了113例从1990年至1997年期间的HLA相合同胞的脐带血受体的记录，并将其与2052例在同一时期的HLA相合同胞的骨髓受体的记录进行比较。研究人群包括15岁或以下的儿童。我们采用考克斯比例风险回归分析来调整潜在的混杂因素，比较了GVHD、造血恢复和生存率。
Background: Umbilical-cord blood as an alternative to bone marrow for hematopoietic stem-cell transplantation may lower the risk of graft-versus-host disease (GVHD).Methods: We studied the records of 113 recipients of cord blood from HLA-identical siblings from the period from 1990 through 1997 and compared them with the records of 2052 recipients of bone marrow from HLA-identical siblings during the same period. The study population consisted of children 15 years of age or younger. We compared the rates of GVHD, hematopoietic recovery, and survival using Cox proportional-hazards regression to adjust for potentially confounding factors.Results: Recipients of cord blood were younger than recipients of bone marrow (median age, 5 years vs. 8 years; P