Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study.
Evaluation of left ventricular diastolic function by fractional area change using cine cardiovascular magnetic resonance: a feasibility study.
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DOI：
10.1186/1532-429x-15-87
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发表时间：
2013-09-26
期刊：
影响因子：
--
通讯作者：
Saito Y
中科院分区：
文献类型：
--
作者：
Okayama S;Nakano T;Uemura S;Fujimoto S;Somekawa S;Watanabe M;Nakajima T;Saito Y
评估左心室舒张功能对心力衰竭的治疗至关重要。我们验证了是否可以通过使用电影心血管磁共振（CMR）测量分数面积变化（FAC）来评估左室舒张功能。我们收集了59例接受超声心动图和CMR检查的患者的临床资料。正常、松弛受损、假异常和限制性左室充盈分别为15例、28例、11例和5例。通过追踪三张MR电影图像的轮廓，我们计算了短轴视图中舒张期前30%的FAC（舒张指数%）。舒张功能受损患者的舒张指数（32.4±7.5）、假正常充盈（25.4±5.6）、限制性充盈（9.5±1.5）明显低于舒张功能正常患者（67.7±10.8）（p < 0.0001），且随着舒张功能障碍的加重，舒张指数明显降低。组织多普勒成像测量的舒张指数与舒张早期二尖瓣环速度呈正相关（r = 0.75, p < 0.0001）。FAC的测量可用于CMR评估左室舒张功能。
Evaluation of left ventricular (LV) diastolic function is essential for the management of heart failure. We verified whether LV diastolic function could be evaluated by measuring the fractional area change (FAC) using cine cardiovascular magnetic resonance (CMR). We collected clinical data from 59 patients who underwent echocardiography and cine CMR. Normal, impaired relaxation, pseudonormal, and restrictive LV filling were observed in 15, 28, 11, and 5 patients, respectively. We calculated FAC during the first 30% of diastole (diastolic-index%) in the short-axis view, by tracing the contours on only three MR cine images. The diastolic index was significantly lower (p < 0.0001) in patients with impaired relaxation (32.4 ± 7.5), pseudonormal filling (25.4 ± 5.6), and restrictive filling (9.5 ± 1.5) compared to those with normal diastolic function (67.7 ± 10.8), and the index decreased significantly with worsening of diastolic dysfunction. The diastolic index correlated positively with early diastolic mitral annular velocity measured by tissue Doppler imaging (r = 0.75, p < 0.0001), respectively. Measurement of FAC can be useful for the evaluation of LV diastolic function using cine CMR.