A LONGITUDINAL-STUDY ON INSULIN-DEPENDENT DIABETES-MELLITUS AND PERIODONTAL-DISEASE
A LONGITUDINAL-STUDY ON INSULIN-DEPENDENT DIABETES-MELLITUS AND PERIODONTAL-DISEASE
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DOI：
10.1111/j.1600-051x.1993.tb00338.x
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发表时间：
1993-03-01
影响因子：
6.7
通讯作者：
AINAMO, J
中科院分区：
文献类型：
--
作者：
SEPPALA, B;SEPPALA, M;AINAMO, J
在这项为期两年的纵向调查中，38名齿状受试者在基线检查一年后评估牙周疾病的进展，22名齿状受试者在两年后评估牙周病的进展，平均病程为18年的胰岛素依赖型糖尿病。这些糖尿病患者的基线年龄在35岁至56岁之间，他们在赫尔辛基大学中央医院第三内科门诊和赫尔辛基卫生中心的两家糖尿病诊所接受治疗。根据他们的长期病历，26名受试者在基线时被确定为控制不佳的胰岛素依赖型糖尿病(PIDD)，平均血糖水平为12.5mmo1/L，平均糖化血红蛋白(HBa1)水平为10.1%。12例患者为胰岛素依赖型糖尿病(CIDD)受试者，血糖平均为6.7 mmol/L，糖化血红蛋白(HbA)平均为9.2%。对于每个个体，在基线时和基线后1年和2年后记录菌斑指数、牙龈指数、牙袋深度、附着丧失、探诊后出血、牙龈退缩和牙槽骨放射学丢失。在基线和基线检查两年后，PIDD受试者的斑块情况与CIDD受试者相似。在基线以及从基线开始的1年和2年后，PIDD受试者比CIDD受试者有更多的牙周炎和探诊后出血(P<；0.05，chi2检验)。无论是在基线时，还是在1年和2年的检查中，长期患有PIDD的受试者都比相应的CIDD受试者失去了更多的牙齿附着体和近侧骨骼(P<；0.01，chi2检验)。在所有3项检查中，PIDD患者的牙龈退缩程度均高于CIDD患者(P<；0.05，chi2检验)。
In the present two-year longitudinal investigation, the progression of periodontal disease was assessed after 1 year from the baseline examination in 38 dentate subjects and after 2 years in 22 dentate subjects with a mean duration of 18 years of insulin-dependent diabetes mellitus. The diabetics, aged 35 to 56 years at baseline, were under medical treatment at the outpatient clinic of the III Department of Medicine, University Central Hospital of Helsinki and at 2 diabetic clinics of the Helsinki Health Centre. Based upon their long-term medical records, 26 subjects were at baseline identified as having poorly controlled insulin-dependent diabetes (PIDD) with a mean blood glucose level of 12.5 mmol/l and a mean glycosylated hemoglobin (HBA1) level of 10.1%. 12 subjects were classified as having controlled insulin-dependent diabetes (CIDD) with a mean blood glucose level of 6.7 mmol/l and a mean HBA, level of 9.2% at baseline. For each individual, recordings were made at baseline and after 1 and 2 years from the baseline for the plaque index, gingival index, pocket depth, loss of attachment, bleeding after probing, gingival recession, and radiographic loss of alveolar bone. At baseline and 2 years after the baseline examination, the PIDD subjects had similar plaque conditions as the CIDD subjects. At baseline and after 1 and 2 years from baseline the PIDD subjects had more gingivitis and bleeding after probing (P < 0.05, chi2-test) than the CIDD subjects. Both at baseline and at the 1-year and 2-year examinations, the long-term PIDD subjects had lost more tooth attachment and approximal bone than the corresponding CIDD subjects (P < 0.01, chi2-test). At all 3 examinations, the PIDD subjects also exhibited more gingival recession than the CIDD subjects (P < 0.05, chi2-test).