SR proteins: To shuttle or not to shuttle, that is the question.
SR proteins: To shuttle or not to shuttle, that is the question.
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DOI：
10.1083/jcb.201705009
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发表时间：
2017-07-03
期刊：
影响因子：
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通讯作者：
Rekosh D
中科院分区：
文献类型：
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作者：
Hammarskjold ML;Rekosh D
Hammarskjold和Rekosh预览了Müller-McNicoll实验室的新结果，表明分化状态调节SR蛋白核质穿梭和功能。富含丝氨酸和丝氨酸的蛋白质在剪接、核输出和翻译中起重要作用。在这个问题上，Botti et al.（2017. https：//doi.org/10.1083/jcb.201610051）显示，先前被认为是核的SRSF 2和SRSF 5与信使RNA一起穿梭到多能P19细胞的细胞质中，但不在分化的细胞中。
Hammarskjold and Rekosh preview new results from the Müller-McNicoll laboratory suggesting that the differentiation state modulates SR protein nucleocytoplasmic shuttling and function. Serine- and arginine-rich proteins play important roles in splicing, nuclear export, and translation. In this issue, Botti et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610051) show that SRSF2 and SRSF5, previously thought to be nuclear, shuttle with messenger RNA to the cytoplasm in pluripotent P19 cells, but not in differentiated cells.