Clinical Significance of Albumin- and Bilirubin-Based Biomarkers in Glaucoma: A Retrospective Case-Control Study.
Clinical Significance of Albumin- and Bilirubin-Based Biomarkers in Glaucoma: A Retrospective Case-Control Study.
复制标题
DOI：
10.1155/2022/8063651
复制
发表时间：
2022
影响因子：
--
通讯作者：
Lu F
中科院分区：
文献类型：
--
作者：
He C;Zhang G;Fu J;Zhang R;Li A;Liu D;Li B;Chen Y;Deng B;Chen Y;Shuai P;Lu F
青光眼是全球失明的第二大原因。青光眼的病因很复杂。除了升高的眼内压（IOP），其他几种机制也与发病机制有关，如氧化应激和全身炎症。据报道，血清白蛋白（ALB）和胆红素（BIL）具有有效的抗氧化特性，有助于维持各种疾病的氧化还原稳态。然而，这些参数和青光眼之间的关联仍然是未知的。在这里，我们进行了一项回顾性病例对照研究，揭示了青光眼患者的血清ALB、总BIL（TBIL）和间接BIL（IBIL）水平明显低于健康对照。此外，青光眼患者的嗜中性粒细胞与ALB（NAR）、嗜中性粒细胞与TBIL（NTBR）和嗜中性粒细胞与IBIL（NIBR）的比值显著升高。此外，有趣的是，较低的ALB和BIL水平以及较高的NAR、NTBR和NIBR与更严重的青光眼性视力损害相关，并且NAR、NTBR和NIBR作为青光眼严重程度的诊断测试显示出良好的准确性，这表明这些指标可能用作疾病严重程度的区分性生物标志物。我们目前的研究结果表明ALB、BIL、NAR、NTBR、NIBL和青光眼之间存在相关性。NAR、NTBR和NIBR可作为青光眼患者病情严重程度的预测指标，ALB/BIL可作为青光眼患者的替代治疗或辅助治疗药物。
Glaucoma is the second leading cause of global blindness. The etiology of glaucoma is complicated. In addition to elevated intraocular pressure (IOP), several other mechanisms have been implicated in pathogenesis, such as oxidative stress and systemic inflammation. Serum albumin (ALB) and bilirubin (BIL) have been reported to have potent antioxidant properties and contribute to maintain redox homeostasis in various diseases. However, associations between these parameters and glaucoma remain mostly unknown. Here, we conducted a retrospective case-control study, revealing that serum ALB, total BIL (TBIL), and indirect BIL (IBIL) levels were markedly lower in glaucoma patients than those in healthy controls. Furthermore, the neutrophil-to-ALB (NAR), neutrophil-to-TBIL (NTBR), and neutrophil-to-IBIL (NIBR) ratios were greatly higher in glaucoma. Additionally, interestingly, lower ALB and BIL levels and higher NAR, NTBR, and NIBR were associated with severer glaucomatous visual impairment, and NAR, NTBR, and NIBR showed good accuracy as diagnostic tests for glaucoma severity, suggesting these indices might be useful as discriminative biomarkers for disease severity. Our current findings demonstrate associations between ALB, BIL, NAR, NTBR, NIBL, and glaucoma. It might be useful to use NAR, NTBR, and NIBR as predictive markers for disease severity and employ ALB/BIL as alternative therapy or adjuvant medicines in glaucoma patients.