Otolith dysfunction alters exploratory movement in mice.
Otolith dysfunction alters exploratory movement in mice.
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DOI：
10.1016/j.bbr.2017.02.031
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发表时间：
2017-05-15
影响因子：
2.7
通讯作者：
Wallace DG
中科院分区：
文献类型：
--
作者：
Blankenship PA;Cherep LA;Donaldson TN;Brockman SN;Trainer AD;Yoder RM;Wallace DG
啮齿动物探索行为的组织似乎依赖于自我运动线索的处理。然而，到目前为止，还没有研究直接检查前庭系统的组织探索运动的贡献。目前的研究顺序分割开放领域的行为进行和停止，以表征运动组织之间的差异控制和耳锥缺陷倾斜小鼠的条件下，有和没有访问视觉线索。在完全黑暗的条件下，倾斜的小鼠表现出相似的行进距离和停止时间的整体，但有显着更多的迂回进展，更大的变化之间的进展，和不稳定的聚集基地，相对于对照组小鼠。在光照条件下，对照组和倾斜组小鼠在所有指标上相似，但进展之间的航向变化除外。这种模式的结果是一致的耳锥缺陷倾斜小鼠使用视觉线索，以弥补受损的自我运动线索处理。这项工作提供了第一个经验证据表明，从耳石器官的信号介导的探索行为的组织，基于一种新的评估空间取向。
The organization of rodent exploratory behavior appears to depend on self-movement cue processing. As of yet, however, no studies have directly examined the vestibular system’s contribution to the organization of exploratory movement. The current study sequentially segmented open field behavior into progressions and stops in order to characterize differences in movement organization between control and otoconia-deficient tilted mice under conditions with and without access to visual cues. Under completely dark conditions, tilted mice exhibited similar distance traveled and stop times overall, but had significantly more circuitous progressions, larger changes in heading between progressions, and less stable clustering of home bases, relative to control mice. In light conditions, control and tilted mice were similar on all measures except for the change in heading between progressions. This pattern of results is consistent with otoconia-deficient tilted mice using visual cues to compensate for impaired self-movement cue processing. This work provides the first empirical evidence that signals from the otolithic organs mediate the organization of exploratory behavior, based on a novel assessment of spatial orientation.