Involvement of the retrosplenial cortex in processing multiple conditioned stimuli
Involvement of the retrosplenial cortex in processing multiple conditioned stimuli
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DOI：
10.1037/0735-7044.122.3.651
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发表时间：
2008-06-01
影响因子：
1.9
通讯作者：
Bucci, David J.
中科院分区：
文献类型：
--
作者：
Keene, Christopher S.;Bucci, David J.
压后皮质（RSP）的病变破坏空间和上下文的学习，这表明RSP可能有一个基本的作用，在处理重叠，或同时提出的刺激。如果是这样的话，那么RSP病变也可能会破坏学习，需要同时处理阶段性条件刺激。在实验1中，对大鼠进行复合特征负辨别任务的训练，其中在某些试验中呈现音调，然后立即提供食物，而在其他试验中，视觉刺激与音调一起沿着呈现，并且不被强化。正常大鼠学会区分试验，但RSP损伤大鼠表现出低水平的条件反射两种类型的试验。实验2表明，这种效果是不是简单地由于一般无法形成协会，因为RSP-lesioned大鼠表现出正常的反应时，视觉刺激单独提出，并与食物配对。这些研究结果支持的观点，即RSP有一个重要的作用，在学习中，涉及同时提出的刺激的处理和理解海马和RSP之间的功能关系的影响。
Lesions of retrosplenial cortex (RSP) disrupt spatial and contextual learning, suggesting that RSP may have a fundamental role in processing overlapping, or simultaneously presented stimuli. If so, then RSP lesions might also be expected to disrupt learning that requires the concurrent processing of phasic conditioned stimuli. In Experiment 1, rats were trained in a compound feature negative discrimination task in which a tone was presented and immediately followed by food on some trials, while on other trials a visual stimulus was simultaneously presented along with the tone and not reinforced. Normal rats learned to discriminate between the trials but RSP-lesioned rats exhibited low levels of conditioning on both types of trials. Experiment 2 demonstrated that this effect was not simply due to a general inability to form associations, since RSP-lesioned rats exhibited normal responding when the visual stimulus was presented alone and paired with food. These findings support the view that RSP has an important role in learning that involves the processing of simultaneously presented stimuli and have implications for understanding the functional relationship between the hippocampus and RSP.