CYTOKINE CONTROL OF LEISHMANIA INFECTION IN THE BALB/C MOUSE - ENHANCEMENT AND INHIBITION OF PARASITE GROWTH BY LOCAL-ADMINISTRATION OF IL-2 OR IL-4 IS SPECIES AND TIME-DEPENDENT
CYTOKINE CONTROL OF LEISHMANIA INFECTION IN THE BALB/C MOUSE - ENHANCEMENT AND INHIBITION OF PARASITE GROWTH BY LOCAL-ADMINISTRATION OF IL-2 OR IL-4 IS SPECIES AND TIME-DEPENDENT
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DOI：
10.1111/j.1365-3024.1992.tb00004.x
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发表时间：
1992-01-01
影响因子：
2.2
通讯作者：
ALEXANDER, J
中科院分区：
文献类型：
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作者：
LEZAMADAVILA, CM;WILLIAMS, DM;ALEXANDER, J
在墨西哥利什曼原虫或重大利什曼原虫感染的 BALB/c 小鼠的足垫中研究了局部注射白细胞介素 2 (IL-2) 或白细胞介素 4 (IL-4) 的治疗潜力。疾病状态通过病理学（通过测量病变大小）和寄生虫学（通过计算受感染足垫的寄生虫总数）来测量。 IL-2（0.5-mu-g/剂量）或IL-4（0.1-mu-g/剂量）在感染后早期、1天和/或15天或晚期、在明显病变出现后施用。根据使用的利什曼原虫种类以及治疗开始的时间，结果存在显着差异。如果在感染的前两周内尽早将 IL-4 注射到受感染的足垫中，则通过足垫厚度和寄生虫数量来测量，大利希伯里氏菌和墨西哥利希伯里氏菌感染都会加剧。矛盾的是，晚期病灶内注射（即在出现可测量的病灶后）IL-4 显着抑制了 L. Major 感染小鼠的病灶大小和寄生虫生长，但对 L. mexicana 感染的小鼠没有影响。无论何时或多久对小鼠受感染的足垫进行治疗，IL-2 对重大利斯特菌感染的病程均没有可测量的影响。然而，早期施用 IL-2 确实加剧了墨西哥乳杆菌病变和寄生虫生长，而晚期治疗则没有效果。一般来说，但并非总是如此，足垫尺寸的增加与寄生虫数量的增加相关。
The therapeutic potential of locally injected interleukin-2 (IL-2) or interleukin-4 (IL-4) was studied in the footpads of Leishmania mexicana or Leishmania major infected BALB/c mice. The disease state was measured both pathologically, by measuring lesion size, and parasitologically, by counting total parasite numbers from infected footpads. IL-2 (0.5-mu-g/dose) or IL-4 (0.1-mu-g/dose) was administered either early, 1 day and/or 15 days after infection, or late, after palpable lesions had developed. Results differed markedly depending on which Leishmania species was used and at what time during the course of disease that therapy commenced. Both L. major and L. mexicana infections, as measured by footpad thickness and parasite number, were exacerbated if IL-4 was injected into the infected footpads early, during the first two weeks of infection. Paradoxically, late intralesional injection (i.e. after measurable lesions had developed) of IL-4 markedly inhibited both lesion size and parasite growth in L. major, though not L. mexicana, infected mice. IL-2 had no measurable effect on the course of L. major infections no matter when or how often, the infected footpads of mice were treated. However, early administration of IL-2 did exacerbate L. mexicana lesion and parasite growth while late treatment had no effect. Generally, but not always, increases in footpad size correlated with increases in parasite number.