Extracellular and Intracellular Factors in Brain Cancer.
Extracellular and Intracellular Factors in Brain Cancer.
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脑癌的细胞外和细胞内因素
DOI：
10.3389/fcell.2021.699103
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发表时间：
2021
影响因子：
5.5
通讯作者：
Gao D
中科院分区：
文献类型：
--
作者：
Kanwore K;Kambey PA;Guo XX;Abiola AA;Xia Y;Gao D
细胞的外部和内部因素对胶质瘤的形成至关重要。据报道，有几个因素和分子与脑癌的发生和发展有关。然而，导致胶质瘤发生的事件的确切顺序仍然是未知的。现有的报道表明，胶质瘤干细胞是胶质瘤的起源细胞。在细胞分裂过程中，染色体断裂，DNA改变增加了细胞基因组修饰和癌基因过度表达的机会。虽然基因改变和癌基因过度表达的风险很高，但并不是每个人都会患上癌症。据报道，在胚胎发育过程中，促进癌症的致癌基因也高度表达，但这种不导致致癌的高表达引发了有关致癌基因在致癌中的作用的问题。癌细胞对药物、细胞凋亡和免疫细胞的抵抗不仅依赖于癌基因的过度表达，还依赖于细胞器机制（线粒体、内质网和细胞骨架）的缺陷。这篇综述讨论了导致癌症的因素；我们报道了细胞器的功能障碍及其在癌变中的作用，而癌基因的过表达通过细胞粘附促进肿瘤的发生、维持和进展。所有这些因素共同代表了癌症及其发展的基本要求。
The external and internal factors of the cell are critical to glioma initiation. Several factors and molecules have been reported to be implicated in the initiation and progression of brain cancer. However, the exact sequence of events responsible for glioma initiation is still unknown. Existing reports indicate that glioma stem cells are the cell of glioma origin. During cell division, chromosome breakage, DNA alteration increases the chance of cell genome modifications and oncogene overexpression. Although there is a high risk of gene alteration and oncogene overexpression, not everyone develops cancer. During embryogenesis, the same oncogenes that promote cancers have also been reported to be highly expressed, but this high expression which does not lead to carcinogenesis raises questions about the role of oncogenes in carcinogenesis. The resistance of cancer cells to drugs, apoptosis, and immune cells does not rely solely on oncogene overexpression but also on the defect in cell organelle machinery (mitochondria, endoplasmic reticulum, and cytoskeleton). This review discusses factors contributing to cancer; we report the dysfunction of the cell organelles and their contribution to carcinogenesis, while oncogene overexpression promotes tumorigenesis, maintenance, and progression through cell adhesion. All these factors together represent a fundamental requirement for cancer and its development.
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影响因子：
4
作者：
Aylon, Yael;Oren, Moshe
通讯作者：
Oren, Moshe
DOI：
10.1083/jcb.201704053
发表时间：
2017-11-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Erdogan B;Ao M;White LM;Means AL;Brewer BM;Yang L;Washington MK;Shi C;Franco OE;Weaver AM;Hayward SW;Li D;Webb DJ
通讯作者：
Webb DJ
影响因子：
64.5
作者：
Cubillos-Ruiz JR;Bettigole SE;Glimcher LH
通讯作者：
Glimcher LH
影响因子：
4.6
作者：
Garcia I;Aldaregia J;Marjanovic Vicentic J;Aldaz P;Moreno-Cugnon L;Torres-Bayona S;Carrasco-Garcia E;Garros-Regulez L;Egaña L;Rubio A;Pollard S;Stevanovic M;Sampron N;Matheu A
通讯作者：
Matheu A
影响因子：
3.7
作者：
Lion M;Raimondi I;Donati S;Jousson O;Ciribilli Y;Inga A
通讯作者：
Inga A