Analysis of sequential cytokine release after ACL reconstruction
Analysis of sequential cytokine release after ACL reconstruction
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DOI：
10.1007/s00167-011-1486-0
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发表时间：
2011-10-01
影响因子：
3.8
通讯作者：
Sutherland, A. G.
中科院分区：
文献类型：
--
作者：
Hayward, A. L.;Deehan, D. J.;Sutherland, A. G.
前交叉韧带断裂是常见的，可能需要手术重建。手术重建旨在恢复膝关节内的正常运动学和生物学。手术重建后的急性期反应仍然不明确，但可能会影响移植物整合通过调制宿主组织remodeling.The非常早期的主机生产的关键细胞因子手术后进行了研究。对14名接受重建手术的患者进行了连续的术前、术后1小时和6小时的研究，检查了急性期反应是非特异性的但个体之间一致的假设，证明了促炎细胞因子的增加。发现单核细胞驱动的、非特异性的IL-1和IL-6释放的一致增加，而不是T细胞衍生的IL-2释放。更有趣的是，发现了非常早期的高浓度的二级生长因子PDGF和TGF-β，提示合成代谢反应。这些数据支持了这样的论点，即在手术重建的膝关节中，合成代谢反应比以前认为的更早开始。
Rupture of the anterior cruciate ligament is common and may necessitate surgical reconstruction. Surgical reconstruction aims to restore normal kinematics and biology within the knee. The acute phase response after surgical reconstruction remains poorly defined but may influence graft integration through modulation of host tissue remodelling.The very early host production of key cytokines after surgery was studied. A consecutive series of 14 patients undergoing reconstructive surgery were studied per-operatively, 1 and 6 h after surgery, examining the hypothesis that the acute phase response would be non-specific but consistent between individuals, demonstrating increases of pro-inflammatory cytokines.A consistent increased release of monocyte-driven, non-specific, IL-1 and IL-6 release but not T cell-derived IL-2 was found. Perhaps, more interestingly, very early high concentrations of secondary growth factors PDGF and TGF-beta suggestive of an anabolic response were found.These data support the contention that an anabolic response starts earlier than previously thought within the surgically reconstructed knee.