Cell migration driven by cooperative substrate deformation patterns.
Cell migration driven by cooperative substrate deformation patterns.
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DOI：
10.1103/physrevlett.104.168104
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发表时间：
2010-04-23
影响因子：
8.6
通讯作者：
Weitz DA
中科院分区：
文献类型：
--
作者：
Angelini TE;Hannezo E;Trepat X;Fredberg JJ;Weitz DA
大多数真核细胞都能感知并对周围环境的机械特性做出反应。这会强烈地影响它们在胚胎发育、组织功能和伤口愈合方面的集体行为。我们使用一个可变形的底物来测量由于底物介导的细胞-细胞相互作用而导致的细胞运动中的集体行为。我们量化了迁移速度和底物变形的空间和时间相关性，并表明细胞驱动的底物变形协同模式介导了细胞之间的远程机械耦合，并控制了集体细胞的迁移。
Most eukaryotic cells sense and respond to the mechanical properties of their surroundings. This can strongly influence their collective behavior in embryonic development, tissue function, and wound healing. We use a deformable substrate to measure collective behavior in cell motion due to substrate mediated cell-cell interactions. We quantify spatial and temporal correlations in migration velocity and substrate deformation, and show that cooperative cell-driven patterns of substrate deformation mediate long-distance mechanical coupling between cells and control collective cell migration.