Porous 3D modeled scaffolds of bioactive glass and photocrosslinkable poly(ε-caprolactone) by stereolithography
Porous 3D modeled scaffolds of bioactive glass and photocrosslinkable poly(ε-caprolactone) by stereolithography
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DOI：
10.1016/j.compscitech.2012.10.014
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发表时间：
2013-01-24
影响因子：
9.1
通讯作者：
Seppala, Jukka V.
中科院分区：
文献类型：
--
作者：
Elomaa, Laura;Kokkari, Anne;Seppala, Jukka V.
已知生物活性玻璃有利于聚合物组织工程支架的细胞相互作用。最有可能的是，当玻璃在支架表面上而没有覆盖物时获得最佳响应。我们结合了光交联聚（ε-己内酯）树脂与生物活性玻璃在快速成型过程中。生物活性玻璃均匀地分布在高度多孔的支架及其表面。在模拟体液中的离子释放测量显示钙和磷浓度迅速下降。磷酸钙沉积在复合支架的表面上的存在表明在体外生物活性。生物活性玻璃可提高成纤维细胞的代谢活性。我们的工作表明，立体光刻能够制造定义明确的复合材料支架，其中生物活性玻璃均匀分布在表面上，并且易于快速离子释放和细胞相互作用。通过立体光刻，可以成功地避免覆盖支架表面上的BG颗粒的不需要的聚合物层。(c)2012爱思唯尔有限公司保留所有权利。
Bioactive glass is known to benefit cell interactions of polymeric tissue engineering scaffolds. Most likely, the best response is obtained when the glass is on the scaffold surface without a cover. We combined a photocrosslinkable poly(epsilon-caprolactone) resin with bioactive glass in a rapid prototyping process. Bioactive glass was homogeneously distributed through the highly porous scaffolds and their surface. Ion release measurements in simulated body fluid revealed a rapid decrease in calcium and phosphorus concentrations. The presence of calcium phosphate deposits on the surface of the composite scaffolds indicated in vitro bioactivity. The bioactive glass increased the metabolic activity of fibroblasts. Our work showed that stereolithography enables the fabrication of well-defined composite scaffolds in which the bioactive glass is homogeneously distributed on the surface and readily available for rapid ion release and cell interactions. By stereolithography, an unwanted polymer layer covering the BG particles on the scaffold surface can be successfully avoided. (c) 2012 Elsevier Ltd. All rights reserved.