High expression of S-phase kinase-associated protein 2 (Skp2) is a strong prognostic marker in oral squamous cell carcinoma patients treated by UFT in combination with radiation.
High expression of S-phase kinase-associated protein 2 (Skp2) is a strong prognostic marker in oral squamous cell carcinoma patients treated by UFT in combination with radiation.
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发表时间：
2005-05
影响因子：
2
通讯作者：
K. Harada;Supriatno;Shin-ichi Kawaguchi;Yuichiro Kawashima;Y. Itashiki;H. Yoshida;Mitsunobu Sato
中科院分区：
文献类型：
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作者：
K. Harada;Supriatno;Shin-ichi Kawaguchi;Yuichiro Kawashima;Y. Itashiki;H. Yoshida;Mitsunobu Sato
P27(Kip1)的低表达与包括口腔鳞状细胞癌(SCC)在内的多种恶性肿瘤的疾病进展和不良预后有关。此外，p27(Kip1)蛋白被认为是由Skp2(S相蛋白相关蛋白2)降解的。这项研究的目的是检验Skp2的表达是否可以作为接受UFT联合放射治疗的口腔鳞癌患者的有用预后因素。应用免疫组织化学方法检测102例口腔鳞癌患者超分割放疗后活检组织中Skp2的表达。并分析了每种表达与临床病理特征和患者生存的关系。Skp2的表达与肿瘤大小(p=0.0462)、颈淋巴转移(p=0.0209)、疗效(p=0.0490)和患者预后(p=0.0002)显著相关。Skp2高表达和低表达的5年生存率分别为40.5%和78.5%，经LOG-RANK检验，差异有统计学意义(P=0.0001)。多因素分析显示生存期缩短与Skp2高表达有关(p=0.0001)。这些结果表明，Skp2可能是UFT联合放疗治疗口腔鳞癌患者的一个有用的预后因子。
Low expression of p27(Kip1) is associated with disease progression and an unfavorable outcome in several malignancies including oral squamous cell carcinoma (SCC). In addition, p27(Kip1) protein is thought to be degraded by Skp2 (S-phase kinase-associated protein 2). The purpose of this study was to examine whether Skp2 expression can be a useful prognostic factor in oral SCC patients treated by UFT in combination with radiation. The Skp2 expression was investigated by immunohistochemistry in biopsy samples from 102 oral SCC patients, who were treated by UFT in combination with radiation. Associations of each expression with the clinicopathological characteristics and patient survival were also analyzed. A significant association was found between Skp2 expression and tumor size (p = 0.0462), cervical lymph node metastasis (p = 0.0209), therapeutic effect (p = 0.0490) and patient outcome (p = 0.0002). The 5-year survival rates of Skp2 high and low expression tumors were 40.5% and 78.5%, respectively, and this difference was significant (p = 0.0001) by log-rank test. Multivariate analysis revealed that reduced term of survival was related to high levels of Skp2 expression (p = 0.0001). These results suggest that Skp2 may be a useful prognostic factor in oral SCC patients treated by UFT in combination with radiation.