THE CLEARANCE OF INTRAVITREAL TRIAMCINOLONE ACETONIDE
THE CLEARANCE OF INTRAVITREAL TRIAMCINOLONE ACETONIDE
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DOI：
10.1016/0002-9394(82)90130-1
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发表时间：
1982-01-01
影响因子：
4.2
通讯作者：
MACHEMER, R
中科院分区：
文献类型：
--
作者：
SCHINDLER, RH;CHANDLER, D;MACHEMER, R
由于高水平的皮质类固醇对于抑制眼内细胞增殖很重要，我们研究了玻璃体内注射的缓释皮质类固醇在兔眼中的清除情况。曲安奈德(0.5 mg)在接受玻璃体切除和晶状体切除联合手术的眼中迅速消失(平均6.5天)，而在仅接受玻璃体切除的眼中消失较慢(平均16.8天)，与未手术的正常兔眼(平均41天)相比。眼底镜下白色晶体的消失与敏感的皮质类固醇清除比色试验有很好的相关性。因此，直接观察是评估皮质类固醇吸收的准确方法。如果用于治疗，这项研究表明，与正常眼相比，接受玻璃体切除手术的眼需要更频繁地注射曲安奈德。
Since high corticosteroid levels are important in achieving inhibition of intraocular cellular proliferation, we studied the clearance of an intravitreally injected slowly dissolving corticosteroid in the rabbit eye. Triamcinolone acetonide (0.5 mg) disappeared rapidly in eyes that underwent a combined vitrectomy and lensectomy (average, 6.5 days) and more slowly in eyes that underwent vitrectomy only (average, 16.8 days) compared with unoperated normal rabbit eyes (average, 41 days). The ophthalmoscopic disappearance of the white crystals correlated well with a sensitive colorimetric test for clearance of the corticosteroid. Direct observation is therefore an accurate method of assessing the absorption of the corticosteroid. If used therapeutically, this study suggests that more frequent injections of triamcinolone acetonide would be necessary in eyes that underwent vitrectomy, compared with normal eyes.