Multiecho approaches to spectroscopic imaging of the brain.
Multiecho approaches to spectroscopic imaging of the brain.
复制标题
大脑光谱成像的多回波方法。
DOI：
10.1111/j.1749-6632.1997.tb46191.x
复制
发表时间：
1997
影响因子：
5.2
通讯作者：
Holtzman,D
中科院分区：
文献类型：
--
作者：
Mulkern,RV;Chao,H;Bowers,JL;Holtzman,D
核磁共振波谱成像（SI）是研究活体脑化学的最有力的工具之一。质子（1H）和磷（31 P）NMR都提供了有价值的生化信息，原则上可以映射到整个大脑，从而增强我们对大脑功能的理解。然而，除了来自组织水的质子和脂肪组织的甘油三酯之外，对活组织的NMR信号有贡献的核的浓度相对较小（毫摩尔）。低浓度的代谢物核降低了传统SI技术的整体灵敏度，使得高质量的代谢物作图成为一个漫长的过程。这个问题已经导致了用于减少SI扫描时间的非常规方法的开发和测试，包括基于多个自旋回波的收集的技术。多回波方法可用于减少SI扫描时间和保持高质量代谢物绘图的程度取决于几个因素。这些包括光谱横向弛豫时间，所需的光谱分辨率，和J-耦合相互作用。我们讨论了应用于活体大脑1H和31 P光谱成像的多回波SI方法的各个技术方面。
Spectroscopic imaging (SI) with nuclear magnetic resonance (NMR) is one of the most powerful tools available for studying brain chemistry in vivo. Both proton (1H) and phosphorus (31P) NMR offer valuable biochemical information that can in principle be mapped throughout the entire brain, thereby enhancing our understanding of brain function. With the exception of protons from tissue water and the triglycerides of adipose tissue, however, nuclei contributing to the NMR signals of living tissue are in relatively small (millimolar) concentrations. The low concentration of metabolite nuclei reduces the overall sensitivity of conventional SI techniques, making high-quality metabolite mapping a lengthy procedure. This problem has led to the development and testing of nonconventional methods for reducing SI scan times, including techniques based on the collection of multiple spin-echoes. The extent to which multiecho methods can be used to decrease SI scan times and maintain high-quality metabolite mapping depends on several factors. These include the spectral transverse relaxation times, the spectral resolution required, and J-coupling interactions. We have discussed these various technical aspects of multiecho SI methods as applied to 1H and 31P spectroscopic imaging of the living brain.