Direct measurement of three-dimensionally reconstructed flow convergence surface area and regurgitant flow in aortic regurgitation: in vitro and chronic animal model studies.
Direct measurement of three-dimensionally reconstructed flow convergence surface area and regurgitant flow in aortic regurgitation: in vitro and chronic animal model studies.
复制标题
主动脉反流中三维重建血流会聚表面积和反流流量的直接测量：体外和慢性动物模型研究。
DOI：
10.1161/01.cir.96.10.3687
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发表时间：
1997
期刊：
影响因子：
37.8
通讯作者：
Sahn,DJ
中科院分区：
文献类型：
--
作者：
Shiota,T;Jones,M;Delabays,A;Li,X;Yamada,I;Ishii,M;Acar,P;Holcomb,S;Pandian,NG;Sahn,DJ
背景使用二维（2D）成像系统评估流动收敛（FC）可能不够准确，无法表征这些通常不对称、复杂的现象。本研究的目的是验证一个三维（3D）的方法，用于确定主动脉瓣反流（AR）的严重程度在实验动物model.Methods和ResultsIn六只羊与手术诱导的慢性AR，20血流动力学不同的状态进行了研究。通过主动脉和肺动脉电磁流量计获得瞬时流速。经计算机控制180°旋转采集后，将彩色多普勒血流图的视频合成数据传输到TomTec计算机中。直接测量3D重建的FC表面积，以及测量的FC面积估计与2D的方法与半球形和半椭圆形的假设，并乘以混叠速度的值，以获得峰值流速。与2D和参考值之间相比，3D和电磁导出的流速之间的一致性更好（对于3D方法，r= 0.94，y =1.0x-0.16，差异=0.02 L/min;对于2D半球方法，r= 0.80，y =1.6x-0.3，差异=1.2 L/min; r= 0.75，y =0.90x+0.2，差异=-0.20 L/min（对于2D半椭圆法）.结论在没有任何几何假设的情况下，3D方法提供了更好的FC区的描绘和FC表面积的直接测量，允许比2D方法更准确地量化AR的严重程度。
BackgroundEvaluation of flow convergence (FC) with two-dimensional (2D) imaging systems may not be sufficiently accurate to characterize these often asymmetric, complex phenomena. The aim of this study was to validate a three-dimensional (3D) method for determining the severity of aortic regurgitation (AR) in an experimental animal model.Methods and ResultsIn six sheep with surgically induced chronic AR, 20 hemodynamically different states were studied. Instantaneous regurgitant flow rates were obtained by aortic and pulmonary electromagnetic flow meters. Video composite data of color Doppler flow mapping images were transferred into a TomTec computer after computer-controlled 180° rotational acquisition. Direct measurement of the 3D reconstructed FC surface areas as well as measurements of FC areas estimated with 2D methods with hemispherical and hemielliptical assumptions were performed, and values were multiplied by the aliasing velocity to obtain peak regurgitant flow rates. There was better agreement between 3D and electromagnetically derived flow rates than there was between the 2D and the reference values (r=.94,y=1.0x−0.16, difference=0.02 L/min for the 3D method;r=.80,y=1.6x−0.3, difference=1.2 L/min for the 2D hemispherical method;r=.75,y=0.90x+0.2, difference=−0.20 L/min for the 2D hemielliptical method).ConclusionsWithout any geometrical assumption, the 3D method provided better delineation of the FC zones and direct measurements of FC surface areas, permitting more accurate quantification of the severity of AR than the 2D methods.