Nanosuspension: An approach to enhance solubility of drugs.
Nanosuspension: An approach to enhance solubility of drugs.
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DOI：
10.4103/2231-4040.82950
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发表时间：
2011-04
影响因子：
1.4
通讯作者：
Agrawal YK
中科院分区：
文献类型：
--
作者：
Patel VR;Agrawal YK
与难溶性药物相关的主要问题之一是生物利用度非常低。对于像伊曲康唑、辛伐他汀和卡马西平这样的药物，问题甚至更复杂，这些药物在水性和非水性介质中溶解性差，属于生物制药分类系统分类的BCS II类。作为纳米混悬剂的制剂是解决这些问题的有吸引力和有前途的替代方案。纳米混悬液由纯的难溶于水的药物组成，没有悬浮在分散体中的任何基质材料。纳米混悬剂制备方法简单，适用于所有水不溶性药物。纳米混悬剂不仅解决了药物溶解度和生物利用度差的问题，而且改变了药物的药代动力学，从而提高了药物的安全性和有效性。本文综述了纳米混悬剂的制备方法、表征及应用。
One of the major problems associated with poorly soluble drugs is very low bioavailability. The problem is even more complex for drugs like itraconazole, simvastatin, and carbamazepine which are poorly soluble in both aqueous and nonaqueous media, belonging to BCS class II as classified by biopharmaceutical classification system. Formulation as nanosuspension is an attractive and promising alternative to solve these problems. Nanosuspension consists of the pure poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of nanosuspension is simple and applicable to all drugs which are water insoluble. A nanosuspension not only solves the problems of poor solubility and bioavailability, but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy. This review article describes the preparation methods, characterization, and applications of the nanosuspension.