Body composition changes in patients with HIV: risk of cardiovascular disease and metabolic abnormalities are possible.
Body composition changes in patients with HIV: risk of cardiovascular disease and metabolic abnormalities are possible.
复制标题
HIV 感染者的身体成分发生变化：可能存在心血管疾病和代谢异常的风险。
DOI：
10.1097/00000446-200512000-00036
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Robinson,Patrick
中科院分区：
文献类型：
--
作者：
Robinson,Patrick
States is currently in its third decade; within that time, the prognosis for someone who is HIV positive has changed radically. A diagnosis that once meant rapidly progressing to AIDS and death now means learning to live with chronic illness. Decreases in HIV-related mortality and morbidity rates are largely due to the advent of highly active antiretroviral therapy (HAART), a potent combination treatment consisting of three or more antiretroviral agents. One of these agents is usually a protease inhibitor (PI); increasingly, however, HAART regimens include a nonnucleoside reverse transcriptase inhibitor instead of or in addition to a PI. The goals of HAART are the maximal, lasting suppression of viral replication and the restoration and preservation of immunologic function. Treatment is lifelong. However, as the use of HAART became widespread, a troubling constellation of body composition and metabolic abnormalities has emerged. Body composition changes, oftenAlthough the precise etiologies of these abnormalities remain unknown, many experts suspect that they are manifestations of antiretroviral drug toxicity. 1 Several studies have specifically implicated PIs. 2-4 However, dyslipidemia was described in people with HIV infection before the introduction of PIs5, 6; and patients on PI-sparing regimens have developed lipid abnormalities and fat redistribution. 4, 7, 8 While it appears likely that both PIs and other classes of antiretrovirals contribute to the development of metabolic abnormalities, 9, 10 the drugs’ effects seem to be modulated substantially by each individual’s history and underlying condition. 11
