Parkinson's Disease in Relation to Pesticide Exposure and Nuclear Encoded Mitochondrial Complex I Gene Variants
Parkinson's Disease in Relation to Pesticide Exposure and Nuclear Encoded Mitochondrial Complex I Gene Variants
复制标题
帕金森病与农药接触和核编码线粒体复合物 I 基因变异的关系
DOI：
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复制
发表时间：
2006
影响因子：
--
通讯作者：
G. Mellick
中科院分区：
文献类型：
--
作者：
E. Corder;G. Mellick
Parkinson's disease (PD) is a common age-related neurodegenerative disorder thought to result from the integrated effects of genetic background and exposure to neuronal toxins. Certain individual nuclear-encoded mitochondrial complex I gene polymorphisms were found to be associated with ∼ 2-fold risk variation in an Australian case-control sample. We further characterized this sample of 306 cases and 321 controls to determine the mutual information contained in the 22 SNPs and, additionally, level of pesticide exposure: five distinct risk sets were identified using grade-of-membership analysis. Of these, one was robust to pesticide exposure (I), three were vulnerable (II, III, IV), and another (V) denoted low risk for unexposed persons. Risk for individual subjects varied > 16-fold according to level of membership in the vulnerable groups. We conclude that inherited variation in mitochondrial complex I genes and pesticide exposure together modulate risk for PD.
帕金森病整个线粒体基因组的序列分析。
DOI：
10.1006/bbrc.2002.6388
发表时间：
2002
期刊：
Biochemical and biophysical research communications.
影响因子：
--
作者：
Vives-Bauza,Cristofol;Andreu,AntoniL;Manfredi,Giovanni;Beal,MFlint;Janetzky,Bernd;Gruenewald,ThomasH;Lin,MichaelT
通讯作者：
Lin,MichaelT
影响因子：
7.7
作者：
Ritz, B;Yu, F
通讯作者：
Yu, F