The Changing Epidemiology of Primary Liver Cancer
The Changing Epidemiology of Primary Liver Cancer
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DOI：
10.1007/s40471-019-00188-3
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发表时间：
2019-06-01
影响因子：
3.3
通讯作者：
McGlynn, Katherine A.
中科院分区：
文献类型：
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作者：
Petrick, Jessica L.;McGlynn, Katherine A.
回顾的目的在过去的几十年里，肝癌被认为是一种肿瘤，几乎只发生在低收入和中等收入国家的高风险人群中。然而，一些高风险人群的发病率一直在下降，而低风险人群的发病率一直在上升，反映了潜在病因的变化。在这篇综述中，我们强调了肝癌流行病学的发展，重点是最近的研究和进展。最近的发现努力减少或消除与主要危险因素，如肝炎B病毒（HBV），丙型肝炎病毒（HCV），黄曲霉毒素B-1（AF B（1））相关的风险已经取得了一些成功。与这些有利的趋势相反，肥胖和糖尿病的联合流行已经开始影响世界各地的肝癌发病率。总结虽然在对抗一些风险因素的影响方面取得了进展，但其他风险因素的日益普遍对应对全球肝癌发病率上升的努力构成了重大威胁。
Purpose of ReviewIn prior decades, liver cancer was viewed as a neoplasm that almost exclusively arose among high-risk populations in low- and middle-income countries. Incidence rates in some high-risk populations, however, have been declining, while rates in low-risk populations have been increasing, reflecting changes in underlying etiology. In this review, we highlight the evolving epidemiology of liver cancer, focusing on recent research and advances.Recent FindingsEfforts to reduce or eliminate the risk associated with major risk factors such as hepatitis B virus (HBV), hepatitis C virus (HCV), and aflatoxin B-1 (AFB(1)) have met with some success. As opposed to these favorable trends, the joint epidemics of obesity and diabetes have begun to affect liver cancer rates around the world.SummaryWhile there has been progress in combating the effects of some risk factors, the increasing prevalence of others poses a major threat to attempts to tackle the rising incidence of liver cancer globally.