The inhibition of blood clotting: An unidentified substance which acts in conjunction with heparin to prevent the conversion of prothrombin into thrombin
The inhibition of blood clotting: An unidentified substance which acts in conjunction with heparin to prevent the conversion of prothrombin into thrombin
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DOI：
10.1152/ajplegacy.1939.125.4.683
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发表时间：
1939-04-01
影响因子：
--
通讯作者：
Seegers, WH
中科院分区：
文献类型：
--
作者：
Brinkhous, KM;Smith, HP;Seegers, WH
肝素阻断凝血酶原转化为凝血酶的作用需要血浆中存在以前未认识到的辅助抑制因子。单独的肝素不能阻断凝血酶的形成，单独的新因子具有非常小的抑制力。然而，两者结合在一起是非常有效的。新的血浆因子被证明是不可透析的，但其身份尚未确定。
The effect of heparin in blocking the conversion of prothrombin into thrombin requires the presence of plasma of an accessory inhibitory factor not previously recognized. Heparin alone does not block the formation of thrombin and the new factor alone has very little inhibitory power. However, the 2 together are highly effective in doing so. The new plasma factor is shown to be non-dialyzable but its identity is not yet established.