Deuteros: software for rapid analysis and visualization of data from differential hydrogen deuterium exchange-mass spectrometry
Deuteros: software for rapid analysis and visualization of data from differential hydrogen deuterium exchange-mass spectrometry
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DOI：
10.1093/bioinformatics/btz022
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发表时间：
2019-09-01
期刊：
影响因子：
5.8
通讯作者：
Politis, Argyris
中科院分区：
文献类型：
--
作者：
Lau, Andy M. C.;Ahdash, Zainab;Politis, Argyris
总结：氢氘交换质谱（HDX-MS）已成为一种强有力的技术，询问蛋白质及其复合物的构象动力学。目前，HDX-MS数据的分析仍然是一个费力的过程，主要是由于缺乏精简的软件来处理大型数据集。我们介绍了Deuteros，这是一个独立的软件，旨在与沃茨DynamX HDX数据分析软件相结合，可以快速分析和可视化差分HDX-MS的数据。
The Summary: Hydrogen deuterium exchange-mass spectrometry (HDX-MS) has emerged as a powerful technique for interrogating the conformational dynamics of proteins and their complexes. Currently, analysis of HDX-MS data remains a laborious procedure, mainly due to the lack of streamlined software to process the large datasets. We present Deuteros which is a standalone software designed to be coupled with Waters DynamX HDX data analysis software, allowing the rapid analysis and visualization of data from differential HDX-MS.