Oxidative Routes to the Heterocyclic Cores of Benzothiazole Natural Products
Oxidative Routes to the Heterocyclic Cores of Benzothiazole Natural Products
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DOI：
10.1055/s-0035-1560722
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发表时间：
2016-01-01
期刊：
影响因子：
2
通讯作者：
Moody, Christopher J.
中科院分区：
文献类型：
--
作者：
Blunt, Christopher E.;Nawrat, Christopher C.;Moody, Christopher J.
以N-乙酰多巴胺和半胱氨酸甲酯为原料，仿生氧化合成了天然产物紫草胺的苯并噻唑核心甲基6-(2-acetylaminoethyl)-4-hydroxy-benzothiazole-2-carboxylate，。在另一种氧化环化反应中，还合成了赤霉唑A的杂环核心乙基6-benzyloxy-5-methoxybenzo[d]thiazole-2-carboxylate，。
Methyl 6-(2-acetylaminoethyl)-4-hydroxy-benzothiazole-2-carboxylate, the benzothiazole core of the natural product violatinctamine, was prepared in a biomimetic oxidative route from N-acetyldopamine and cysteine methyl ester. In an alternative oxidative cyclization, ethyl 6-benzyloxy-5-methoxybenzo[d]thiazole-2-carboxylate, the heterocyclic core of erythrazole A, was also prepared.