Influence of brain catalase on ethanol-induced loss of righting reflex in mice
Influence of brain catalase on ethanol-induced loss of righting reflex in mice
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DOI：
10.1016/s0376-8716(01)00142-9
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发表时间：
2001-12-01
影响因子：
4.2
通讯作者：
Aragon, CMG
中科院分区：
文献类型：
--
作者：
Correa, M;Sanchis-Segura, C;Aragon, CMG
本文研究了醋酸铅和3-氨基-1，2，4-三唑（AT）对乙醇引起的翻正反射丧失（LORR）和脑过氧化氢酶活性的影响，试图证实过氧化氢酶参与乙醇引起的效应的早期观察结果。在试验前7天或5小时，将醋酸铅（0或100 mg/kg）或AT（0或500 mg/kg）注射（急性）到小鼠体内。其他小鼠暴露于含有500 ppm醋酸铅的饮用液60天。在试验当天，小鼠接受腹膜内注射乙醇（4.0或4.5 g/kg），并记录LORR的持续时间。急性铅处理的动物表现出减少的LORR的持续时间，然而，醋酸铅和AT治疗的慢性管理乙醇产生的LORR的持续时间增加。此外，脑过氧化氢酶活性在急性铅预处理的动物表现出显着的诱导，而在慢性铅和AT治疗的小鼠减少。这些结果表明，脑过氧化氢酶的活性，并暗示中央形成的乙醛，可以调节乙醇诱导的LORR。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
The effect of lead acetate and 3-amino-1, 2, 4-triazole (AT) on ethanol-induced loss of righting reflex (LORR) and brain catalase activity was studied in an attempt to confirm earlier observations on the involvement of catalase in ethanol-induced effects. Lead acetate (0 or 100 mg/kg) or AT (0 or 500 mg/kg) was injected (acutely) into mice 7 days or 5 h before testing. Other mice were exposed to drinking fluid containing 500 ppm lead acetate for 60 days. On the test day, mice received an intraperitoneal injection of ethanol (4.0 or 4.5 g/kg) and the duration of LORR was recorded. Acute lead-treated animals demonstrated a reduction in the duration of the LORR, However, both chronic administration of lead acetate and AT treatment increased the duration of ethanol-produced LORR. Furthermore, brain catalase activity in acute lead pretreated animals showed a significant induction, whereas it was reduced in chronic lead and AT treated mice. These results suggest that brain catalase activity, and by implication centrally formed acetaldehyde, may modulate ethanol-induced LORR. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.