Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States.
Cytomegalovirus Antibody Elevation in Bipolar Disorder: Relation to Elevated Mood States.
复制标题
双相情感障碍中的巨细胞病毒抗体升高：与情绪状态升高的关系。
DOI：
10.1155/2015/939780
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发表时间：
2015
影响因子：
3.1
通讯作者：
McInnis,MG
中科院分区：
文献类型：
--
作者：
Prossin,AR;Yolken,RH;Kamali,M;Heitzeg,MM;Kaplow,JB;Coryell,WH;McInnis,MG
情绪状态的神经生物学因暴露于日常压力源而变得复杂（例如，心理社会、无处不在的环境感染（如巨细胞病毒），每种感染都在潜伏和重新激活之间波动。CMV再活化诱导促炎细胞因子（例如，TNF-α）与双相情感障碍（BD）中神经毒性代谢物的诱导和情绪状态的存在相关。巨细胞病毒再激活是否与双相情感障碍诊断（特质）或特定的情绪状态有关尚不清楚。我们研究了139例BD I型和99例健康对照，以确定疱疹病毒科的IgG抗体浓度（例如，CMV、HSV-1和HSV-2）与BD-I诊断和特定情绪状态相关。BD-I组CMV抗体浓度高于健康对照组（T234= 3.1，Puncorr = 0.002;Pcorr= 0.006），但HSV-1（P> 0.10）和HSV-2（P> 0.10）无差异。与情绪正常的BD‐I志愿者相比，情绪升高的BD‐I志愿者的CMV IgG较高（P< 0.03），但在抑郁情绪中无差异（P> 0.10）。虽然BD‐I诊断，情绪状态和CMV抗体之间的关系令人鼓舞，但它们受到研究的横截面性质的限制。然而，需要进一步的测试来复制结果，并确定CMV感染的重新激活是否会加剧BD‐I的情绪状态升高。
The neurobiology of mood states is complicated by exposure to everyday stressors (e.g., psychosocial, ubiquitous environmental infections like CMV), each fluctuating between latency and reactivation. CMV reactivation induces proinflammatory cytokines (e.g., TNF‐α) associated with induction of neurotoxic metabolites and the presence of mood states in bipolar disorder (BD). Whether CMV reactivation is associated with bipolar diagnoses (trait) or specific mood states is unclear. We investigated 139 BD type I and 99 healthy controls to determine if concentrations of IgG antibodies to Herpesviridae (e.g., CMV, HSV‐1, and HSV‐2) were associated with BD‐I diagnosis and specific mood states. We found higher CMV antibody concentration in BD‐I than in healthy controls (T234= 3.1,Puncorr= 0.002;Pcorr= 0.006) but no difference in HSV‐1 (P> 0.10) or HSV‐2 (P> 0.10). Compared to euthymic BD‐I volunteers, CMV IgG was higher in BD‐I volunteers with elevated moods (P< 0.03) but not different in depressed moods (P> 0.10). While relationships presented between BD‐I diagnosis, mood states, and CMV antibodies are encouraging, they are limited by the study’s cross sectional nature. Nevertheless, further testing is warranted to replicate findings and determine whether reactivation of CMV infection exacerbates elevated mood states in BD‐I.