Construction of β-Trifluoromethyl Enol Ether via Base-Promoted C-O Coupling and Rearrangement of Hydrogen Atom
Construction of β-Trifluoromethyl Enol Ether via Base-Promoted C-O Coupling and Rearrangement of Hydrogen Atom
复制标题
通过碱促进的C-O偶联和氢原子重排构建β-三氟甲基烯醇醚
DOI：
10.1021/acs.joc.7b00396
复制
发表时间：
2017-05-05
影响因子：
3.6
通讯作者：
Liu, Zhao-Tie
中科院分区：
文献类型：
--
作者：
Dai, Kun;Wang, Kuan;Liu, Zhao-Tie
提出了一种新的、高效率和高选择性的β-三氟甲基烯醇醚的构建方法，该方法通过碱诱导/促进的三氟甲基氯乙烯和苯酚的C-O偶联进行，具有广泛的底物范围。通过密度泛函理论的计算，揭示了反应机理，特别是高选择性，并得到了实验观察的支持。
A novel, high-efficiency and high-selectivity construction of beta-trifluoromethyl enol ether via base-induced/promoted C-O coupling of trifluoromethylated vinyl chloride and phenols is presented with a broad substrate scope. The reaction mechanism, especially the significantly high selectivity, was excavated and understood via DFT calculation and is well supported by the experimental observation.